ID   A0A3E2N3T7_9CLOT        Unreviewed;       436 AA.
AC   A0A3E2N3T7;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Permease IIC component {ECO:0000256|PIRNR:PIRNR006351};
GN   ORFNames=DS742_28230 {ECO:0000313|EMBL:RFZ75581.1};
OS   Clostridium indicum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=759821 {ECO:0000313|EMBL:RFZ75581.1, ECO:0000313|Proteomes:UP000260680};
RN   [1] {ECO:0000313|EMBL:RFZ75581.1, ECO:0000313|Proteomes:UP000260680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PI-S10-A1B {ECO:0000313|EMBL:RFZ75581.1,
RC   ECO:0000313|Proteomes:UP000260680};
RA   Krishna G., Summeta K., Shikha S., Prabhu P.B., Suresh K.;
RT   "New species, Clostridium PI-S10-A1B.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active -transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane.
CC       {ECO:0000256|PIRNR:PIRNR006351}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFZ75581.1}.
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DR   EMBL; QOHO01000143; RFZ75581.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3E2N3T7; -.
DR   OrthoDB; 1641940at2; -.
DR   Proteomes; UP000260680; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR004501; PTS_EIIC_3.
DR   InterPro; IPR004796; PTS_IIC_cello.
DR   NCBIfam; TIGR00410; lacE; 1.
DR   PANTHER; PTHR33989; -; 1.
DR   PANTHER; PTHR33989:SF10; PERMEASE IIC COMPONENT; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   PIRSF; PIRSF006351; PTS_EIIC-Cellobiose; 1.
DR   PROSITE; PS51105; PTS_EIIC_TYPE_3; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR006351};
KW   Reference proteome {ECO:0000313|Proteomes:UP000260680};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR006351}.
FT   TRANSMEM        28..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..423
FT                   /note="PTS EIIC type-3"
FT                   /evidence="ECO:0000259|PROSITE:PS51105"
SQ   SEQUENCE   436 AA;  46412 MW;  1BF8FC022BAA901C CRC64;
     MKDKLMNGML SAAGAMQTQR HLAAIKNAFM SLLPIIIIGS FCTLFSNVIC NTTPGFFSLA
     NIPGLSFLGK LNPMFTAANY GTMNFIAIGC VILIAMELGE HYGITDKALP VVALGAYISL
     CAFTASGKAA DGTEVVVTNV LSRVYTNAQG LFVGMFASIA ATEIYCRLVK SGKLEIHMPE
     GVPSNVARSF TILFPSLITV VIISAVGMIF EMATGMTLFN AITAFIQRPL SNILTSFPGY
     ITLIFITTVL WTFGIHGTQV TKAVYEPILL AAFAENEAAY AAGTAIPNII NTPFMSCFST
     VTGAGITGGL IIAIMLFSKR EDYRAIAKLA LPCALFNINE PLTFGLPIVM NPVLAIPFMI
     SPAVSATFAY AMTKIGFCAR MVVNAPWTTP PGLMAFLCSG GNIGAAVTQI ICILLAFVVY
     IPFVLIANKQ QVVTEE
//