ID A0A3E2NGS0_9CLOT Unreviewed; 213 AA.
AC A0A3E2NGS0;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN ORFNames=DS742_04395 {ECO:0000313|EMBL:RFZ80209.1};
OS Clostridium indicum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=759821 {ECO:0000313|EMBL:RFZ80209.1, ECO:0000313|Proteomes:UP000260680};
RN [1] {ECO:0000313|EMBL:RFZ80209.1, ECO:0000313|Proteomes:UP000260680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PI-S10-A1B {ECO:0000313|EMBL:RFZ80209.1,
RC ECO:0000313|Proteomes:UP000260680};
RA Krishna G., Summeta K., Shikha S., Prabhu P.B., Suresh K.;
RT "New species, Clostridium PI-S10-A1B.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFZ80209.1}.
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DR EMBL; QOHO01000013; RFZ80209.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3E2NGS0; -.
DR OrthoDB; 9773765at2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000260680; Unassembled WGS sequence.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.8.610; SirC, precorrin-2 dehydrogenase, C-terminal helical domain-like; 1.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR042518; SirC_C.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000260680}.
SQ SEQUENCE 213 AA; 23921 MW; 33DF3BEB91B237DA CRC64;
MAYFPFFVEL EGKKCLIAGG GMVAYRKALV LKDFGPEITV VAVEMIPEME QLASRCEKSM
TLIKRGFEDR DIQEADFVIA ATSDEELNRH ISVICRRRKI PVNVVDVQEE CSFIFPALIK
EEDIVVGIST GGSSPTIAQY LKKRFQEAIP SGFGMLASQL GTYRELVKEK VPSLAVRTEI
FKTMVKEGIR QGGVFTREQA IELIERKLGE HEQ
//
