ID A0A3E2XLT8_9FIRM Unreviewed; 711 AA.
AC A0A3E2XLT8;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Precorrin-6A reductase {ECO:0000313|EMBL:RGC47613.1};
DE EC=1.3.1.54 {ECO:0000313|EMBL:RGC47613.1};
GN Name=cobK {ECO:0000313|EMBL:RGC47613.1};
GN ORFNames=DW747_08045 {ECO:0000313|EMBL:RGC47613.1};
OS Coprococcus catus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=116085 {ECO:0000313|EMBL:RGC47613.1, ECO:0000313|Proteomes:UP000261231};
RN [1] {ECO:0000313|EMBL:RGC47613.1, ECO:0000313|Proteomes:UP000261231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM28-39 {ECO:0000313|EMBL:RGC47613.1,
RC ECO:0000313|Proteomes:UP000261231};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGC47613.1}.
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DR EMBL; QVFD01000006; RGC47613.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3E2XLT8; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000261231; Unassembled WGS sequence.
DR GO; GO:0016994; F:precorrin-6A reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0008176; F:tRNA (guanine(46)-N7)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR003723; Precorrin-6x_reduct.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase_Trmb.
DR NCBIfam; TIGR02469; CbiT; 1.
DR NCBIfam; TIGR00715; precor6x_red; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF02571; CbiJ; 1.
DR Pfam; PF02390; Methyltransf_4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS51014; COBK_CBIJ; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Oxidoreductase {ECO:0000313|EMBL:RGC47613.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261231};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 317..499
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 711 AA; 77650 MW; 9C7F7F93AD6F6A6B CRC64;
MPLLSGYDMI ALYPLIFMWI SKISTDEEIF TMKNILLFAG TTEGRLLAEF LIHQPVRLHT
AVATSYGASL LPSAPSMTVS SHRMNEAQII DFIQQQHFDL VLDATHPYAS EASANISGAC
ASTQVPYLRI LRDCQTSADT SSNSIHPSEI FVDTTAEAVD CLNHQEGPVF LTTGSKTLPD
FMEISNASDR VFVRILPNAE MLAACMSLGL PASHIFCMQG PFDVGMNTAT IQHICRLWEK
DHPDSNLSET PLYMVTKQSG RTGGFDEKLE AAAQAQVPVL IIGHPVRENG LSLSESYHWL
SNWIGTFPSE STAKQTVSLI GTGMCADQLT LEADRTLKNC DVIIGAGRML QMAEHYHKPT
FCSYNYPAIT DYMLSHPEYQ HFAVLFSGDI GFYSGAASLR RCLEGQPFKI EAFSGISSPI
HFLNTIGKTW SDVHLISCHG QTASVISHVR CHAKTLALLG KPDDAANISQ KMIDYGLSNV
RLYIGADLKQ PDEQIISGSP ADFLEQTFSA LSLIYIENPN AEPLPVTYGL SDDAFIRGKV
PMTKSEIRSV VLSKLKLTKN AILFDIGAGT GSIAIEAAQQ IPDGRVYAIE RNPDGLDLIK
ENSLRLQADN LTIVSGTAPE SLDALPAATH AFIGGSAGHL KEILQLLYSR NPEIRVVITA
ITLETIGQIM ALQKEMALPE PEIIQIQVSS AKKAGPYHLM QGQNPVYIVS F
//
