ID A0A3F2XYM5_DEKBR Unreviewed; 342 AA.
AC A0A3F2XYM5;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Elongation of fatty acids protein {ECO:0000256|RuleBase:RU361115};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU361115};
GN Name=ELO2 {ECO:0000313|EMBL:VUG16995.1};
GN ORFNames=DEBR0S1_30834G {ECO:0000313|EMBL:VUG16995.1}, HII12_000491
GN {ECO:0000313|EMBL:KAF6015928.1};
OS Dekkera bruxellensis (Brettanomyces custersii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Brettanomyces.
OX NCBI_TaxID=5007 {ECO:0000313|EMBL:VUG16995.1, ECO:0000313|Proteomes:UP000478008};
RN [1] {ECO:0000313|EMBL:VUG16995.1, ECO:0000313|Proteomes:UP000478008}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Friedrich A., Schacherer J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF6015928.1, ECO:0000313|Proteomes:UP000568158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AWRI1613 {ECO:0000313|EMBL:KAF6015928.1,
RC ECO:0000313|Proteomes:UP000568158};
RX PubMed=32592028;
RA Varela C., Bartel C., Onetto C., Borneman A.;
RT "Targeted gene deletion in Brettanomyces bruxellensis with an expression-
RT free CRISPR-Cas9 system.";
RL Appl. Microbiol. Biotechnol. 104:7105-7115(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an acyl-CoA + H(+) + malonyl-CoA = a 3-oxoacyl-CoA + CO2 +
CC CoA; Xref=Rhea:RHEA:50252, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:58342,
CC ChEBI:CHEBI:90726; Evidence={ECO:0000256|RuleBase:RU361115};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50253;
CC Evidence={ECO:0000256|RuleBase:RU361115};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ELO family. {ECO:0000256|RuleBase:RU361115}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361115}.
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DR EMBL; JABCYN010000005; KAF6015928.1; -; Genomic_DNA.
DR EMBL; CABFWN010000001; VUG16995.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3F2XYM5; -.
DR STRING; 5007.A0A3F2XYM5; -.
DR Proteomes; UP000478008; Unassembled WGS sequence.
DR Proteomes; UP000568158; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR030457; ELO_CS.
DR InterPro; IPR002076; ELO_fam.
DR PANTHER; PTHR11157:SF134; ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6; 1.
DR PANTHER; PTHR11157; FATTY ACID ACYL TRANSFERASE-RELATED; 1.
DR Pfam; PF01151; ELO; 1.
DR PROSITE; PS01188; ELO; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160,
KW ECO:0000256|RuleBase:RU361115};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832,
KW ECO:0000256|RuleBase:RU361115};
KW Lipid biosynthesis {ECO:0000256|RuleBase:RU361115};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361115};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361115};
KW Reference proteome {ECO:0000313|Proteomes:UP000478008};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361115};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361115};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361115}.
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361115"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361115"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361115"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361115"
FT REGION 320..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 39437 MW; 3FA4E048A22425A0 CRC64;
MGNSIIPLPT IDRPFGFYLF GVFDKVVTSV TGGRFIPSQF EFVENETFLS DLPHVAIAIA
MYYILVFGGR FLLKKVGAKP LSLRFQFQIH NMFLTTVSFL LVALMYEQLI PMIAHHGLYF
SICDGQAWTK EMTTLYYLNY LVKFYEFLDT YYLVLKQKKL TFLHTYHHGA TALLCYTQLI
GTTSISWVPI TLNLDVHVLM YWYYFLSARG IHVWWKEWVT RFQILQFILD LIFIYYATAI
KVGHAIAPEY VCKRCAGSPL ATISGCAIIS SYLVLFIAFY IDIYKKSTKK SKVVRRVRGG
VAAKVNEYVL LDKQTVQDNY DSNTGSPLPT KRRLHRGEKS EL
//
