ID A0A3F2YKJ8_SHEVT Unreviewed; 1010 AA.
AC A0A3F2YKJ8;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA polymerase {ECO:0000256|ARBA:ARBA00015749, ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU000442};
GN ORFNames=SPPV_35 {ECO:0000313|RefSeq:NP_659611.1};
OS Sheeppox virus (strain Turkey/TU-V02127) (SPPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Capripoxvirus; Sheeppox virus.
OX NCBI_TaxID=654928 {ECO:0000313|Proteomes:UP000008028, ECO:0000313|RefSeq:NP_659611.1};
OH NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1] {ECO:0000313|RefSeq:NP_659611.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TU-V02127 {ECO:0000313|RefSeq:NP_659611.1};
RX PubMed=12021338;
RA Tulman E.R., Afonso C.L., Lu Z., Zsak L., Sur J.H., Sandybaev N.T.,
RA Kerembekova U.Z., Zaitsev V.L., Kutish G.F., Rock D.L.;
RT "The genomes of sheeppox and goatpox viruses.";
RL J. Virol. 76:6054-6061(2002).
RN [2] {ECO:0000313|RefSeq:NP_659611.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TU-V02127 {ECO:0000313|RefSeq:NP_659611.1};
RG NCBI Genome Project;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_659611.1}
RP IDENTIFICATION.
RC STRAIN=TU-V02127 {ECO:0000313|RefSeq:NP_659611.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR RefSeq; NP_659611.1; NC_004002.1.
DR KEGG; vg:944672; -.
DR Proteomes; UP000008028; Segment.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR013617; DNA-dir_DNA_pol_B_vir_insert.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR013660; DNApol_B_exo_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF08408; DNA_pol_B_3; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08452; DNAP_B_exo_N; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000008028};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 1..22
FT /note="DNA polymerase B exonuclease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08452"
FT DOMAIN 68..349
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 350..481
FT /note="DNA-directed DNA polymerase family B viral insert"
FT /evidence="ECO:0000259|Pfam:PF08408"
FT DOMAIN 494..990
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 1010 AA; 117608 MW; 886450074BE50174 CRC64;
MEIKCINWFE SKGNERFLFL KARNRRSETI FLRFNFYFYY AVTEDVYLSL SPPAYSSDFL
GNMNLIDISE RVSNHVTDVE KKKTNVNVWL IKEPQKRNIP KAIMEEFLNV SWFFISNNIS
PEGCYSINVE KLKKINEQCY HCDCPKECFA TPINRFNINR SYLFLDIECQ FDKKFPSVFT
NPVSHISCCY IDLTNLEFKF TLINEDILSN KDKKDATLKG YYKAKSVSDV DYTKEIIICS
EITMLKVAKK LLELTFDYVV TFNGNNFDLR YISNRLELLT SGKIIFKSPD KKEHVHLCIY
ERNLSSHKGV GGVANTTYHV NNNNGTTFFD LYTYIQKSEK LDSYKLDSIS KNAFSCSVKL
KSENDNLVTF VGDNTTDDIG KISSFSEVLS TGNYITIVDD VFKIVDKSVG NDKFQLTILN
KNNTLKKNID NDIYTISFGK DDVNLSDMYK NYDLNTSIEM AKYCIHDACL CKYLWNYYGI
ETKIDAGAFT YILPQSMVFE YRASTLIKGP LLNLLLDEKI ILSRSEKKNK YHYEGGKVFA
PKQKMFINNV LIFDYNSLYP NVCLFGNLSP ETLVSVFVAN NRLEAEINKQ EIEKMYPPPR
YISIHCEPRC DDLISEIAVF DRNVEGIIPK LLKTFLTERA RYKKKYKEAT LSTDKSIYNS
MQYTYKIISN SVYGLMGFKN SVLYSYSSAK SCTAIGRKMI DYLNSVLNGS KVENGKVLLA
TKPINPFFED GRNEDINIDT KLPTEYTFNF KSVYGDTDSI FLEIDTNDIS KSIRVAKELE
KIINEKILFS NFKIEFEAVY KNLIMQSKKK YTTLKYLPFF TNESIPERIN KGTSETRRDV
SKFHKYMIRI YKTRLLQMLS SGNMSSVQVC VEILSSLESD LQIEFETKTA PLDMFLLSRT
HHCNYKSSDN PNMYLVNEYN KNNDEIIEIG ERYYFAYICN KKEPWQKKLV NIKTYERIID
RSFKLKSTER IFYEVYFKRL ATEIVNLLDN KVLSTSFFEK MFGTRPIFYN
//
