ID A0A3F2YPB8_HUMAN Unreviewed; 616 AA.
AC A0A3F2YPB8;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Zinc finger protein 266 {ECO:0000313|Ensembl:ENSP00000466714.2};
GN Name=ZNF266 {ECO:0000313|Ensembl:ENSP00000466714.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466714.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000466714.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000466714.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC011451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006722683.1; XM_006722620.2.
DR RefSeq; XP_006722684.1; XM_006722621.2.
DR RefSeq; XP_006722685.1; XM_006722622.2.
DR RefSeq; XP_006722686.1; XM_006722623.3.
DR RefSeq; XP_011525946.1; XM_011527644.1.
DR RefSeq; XP_016881643.1; XM_017026154.1.
DR RefSeq; XP_016881644.1; XM_017026155.1.
DR AlphaFoldDB; A0A3F2YPB8; -.
DR SMR; A0A3F2YPB8; -.
DR MassIVE; A0A3F2YPB8; -.
DR PeptideAtlas; A0A3F2YPB8; -.
DR Antibodypedia; 12591; 195 antibodies from 24 providers.
DR DNASU; 10781; -.
DR Ensembl; ENST00000592904.7; ENSP00000466714.2; ENSG00000174652.20.
DR GeneID; 10781; -.
DR MANE-Select; ENST00000592904.7; ENSP00000466714.2; NM_001370374.1; NP_001357303.1.
DR CTD; 10781; -.
DR HGNC; HGNC:13059; ZNF266.
DR VEuPathDB; HostDB:ENSG00000174652; -.
DR GeneTree; ENSGT00940000162380; -.
DR OMA; EDPFECK; -.
DR OrthoDB; 4747146at2759; -.
DR ChiTaRS; ZNF266; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000174652; Expressed in granulocyte and 201 other cell types or tissues.
DR ExpressionAtlas; A0A3F2YPB8; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF90; KRAB DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00614; ZnF_BED; 2.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3F2YPB8,
KW ECO:0007829|ProteomicsDB:A0A3F2YPB8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 39..109
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 223..250
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 251..278
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 279..306
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 307..334
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 335..362
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 363..390
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 391..418
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 419..446
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 447..474
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 475..502
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 503..530
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 531..558
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 559..586
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 587..614
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 597..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 69851 MW; A439729303909D26 CRC64;
MAATDLSYGL YRDPVCLQEK TEVERVVADC LTNCYQDSVT FDDLAVDFTP EEWTLLDPTQ
RNLYRDVMLE NYKNLATVGY QLFKPSLISW LEQEESRTVQ RGDFQASEWK VQLKTKELAL
QQDVLGEPTS SGIQMIGSHN GGEVSDVKQC GDVSSEHSCL KTHVRTQNSE NTFECYLYGV
DFLTLHKKTS TGEQRSVFSQ CGKAFSLNPD VVCQRTCTGE KAFDCSDSGK SFINHSHLQG
HLRTHNGESL HEWKECGRGF IHSTDLAVRI QTHRSEKPYK CKECGKGFRY SAYLNIHMGT
HTGDNPYECK ECGKAFTRSC QLTQHRKTHT GEKPYKCKDC GRAFTVSSCL SQHMKIHVGE
KPYECKECGI AFTRSSQLTE HLKTHTAKDP FECKICGKSF RNSSCLSDHF RIHTGIKPYK
CKDCGKAFTQ NSDLTKHART HSGERPYECK ECGKAFARSS RLSEHTRTHT GEKPFECVKC
GKAFAISSNL SGHLRIHTGE KPFECLECGK AFTHSSSLNN HMRTHSAKKP FTCMECGKAF
KFPTCVNLHM RIHTGEKPYK CKQCGKSFSY SNSFQLHERT HTGEKPYECK ECGKAFSSSS
SFRNHERRHA DERLSA
//
