ID A0A3F2YWU8_9DIPT Unreviewed; 981 AA.
AC A0A3F2YWU8;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF010723-PB, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF010723-PB}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF010723-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR EMBL; AXCN02001792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A3F2YWU8; -.
DR STRING; 69004.A0A3F2YWU8; -.
DR EnsemblMetazoa; AFAF010723-RB; AFAF010723-PB; AFAF010723.
DR VEuPathDB; VectorBase:AFAF010723; -.
DR OrthoDB; 48011at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 306..581
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 220..272
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 917..976
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 981 AA; 113367 MW; 3C9F8D4CD33DC63F CRC64;
MAQLLRGWSS IDPRFRQIRP VAYTAVSRVN FSGFTTADKG NGAGGNGGGS CHSTAWSRYN
YYRQQEFLRP PNASGWQYSY GGHRNYGMLL GRVLRGVLKL RYLVLGGAIG GGVTLNKRYE
EWKDGLPDMK WLEEVLPDNE KWAGFTKNLL AVKDAVKDSI EIDPRLKQLS EHKINEWRQW
FDQRLDNAIE AAETQQNPQI ETTKEELRAK NTVNAKGLGA EDSRKRVDTL QAQVDSLQTE
IMNVQLKYQR EVEKLEKENR DLRQQYLILK TNRKQPTKKR IKKSLIDMYS EVLDELSGYD
TSYTTADHLP RVVVVGDQSS GKTSVLESIA QARIFPRGSG EMMTRAPVKV TLSEGPYHVA
QFRDSEREYD LTKESDLSDL RREVEIRMRN SVRGGKTVSM DVISMTVKGP GLQRMVLVDL
PGIISTQTVD MAPDTRDQIK HMTEHYMSNP NAIILCIQDG SVDAERSNVT DLVSQCDPLG
KRTIFVLTKV DLAEDLADPN RIRKILSGKL FPMKALGYFA VVTGRGRKDD SIETIREYEE
KFFKNSKLFQ SGVTMSHQVT TRNLSLAVAD RFWKMVRETI EQQADAFKAT RFNLETEWKN
NFPRLRESGR DELFEKAKGE VLDEVVNLSQ VSAKKWEELM NTKLWEKLSS YVFENIYLPA
AQSGSQNSFN TMVDIKLRQW AEQALPAKSV EAGWEALQKE FQHLMEVARR TPDHDDLYDN
LKSAVIDEAI RRHSWEDKAI DMLRVIQLNT LEDRSVHDKQ EWDQAVRFFE ASVKDKLLAT
EKTIGEMFGP STSQKWLQWR SSTEDQNKRR QVKSELDKIL DSDTKHSPTL SYDELTTVRK
NLQRCNVEVE TDYIRETWYP IYRRHFLKQA LNRAYDCRKA YYLYSQQGND CEINCSDVVL
FWRIQQVIKV TANALRQQVI NREARRLDKE IKEVLDEYGE DDEKKQQLLT GKRVQLAEEL
IRVRQIQEKL EEFINALNLE K
//
