ID A0A3F2Z1Y3_ANOQN Unreviewed; 1050 AA.
AC A0A3F2Z1Y3;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA017058-PB, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA017058-PB}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA017058-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR STRING; 34691.A0A3F2Z1Y3; -.
DR EnsemblMetazoa; AQUA017058-RB; AQUA017058-PB; AQUA017058.
DR VEuPathDB; VectorBase:AQUA017058; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd13361; PH_PLC_beta; 1.
DR Gene3D; 2.30.29.240; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR Gene3D; 1.20.1230.10; Phospholipase C beta, distal C-terminal domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR016280; PLC-beta.
DR InterPro; IPR042531; PLC-beta_C_sf.
DR InterPro; IPR037862; PLC-beta_PH.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF149; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF17787; PH_14; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PIRSF; PIRSF000956; PLC-beta; 2.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF69989; C-terminal domain of PLC-beta; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133}.
FT DOMAIN 326..442
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 445..570
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 760..787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 882..909
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 232..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 114414 MW; 750BF2E38683BEAA CRC64;
MASLLTAADR QHSTTQSPQS LSGSCSPRNA ASPNANAAAA ATTAGGQPTA GGGGNTAVAL
NNPTAVKLGV MDVPKALQDG EKFIKWDEDS CNGTPVTLRV DVKGFFLYWV DQNHEMDMLD
IATIRDVRTG QYAKKPRDMK LRQIVTMGSQ DTLEEKTVTV CYGADFVNVN FINFCCTRKE
IARLWCDELI RMAYNLTQLN GPAIMFLQKA YTKLCLQVDK SGKIPVKXXA NPSLPPSQQD
EPNGTVVVSN NNGTATPLQA TGNGEIPHHA PPLQQIRQSS KESTGSSDTD SSSDDESMPG
TVVGPIGASE ADKVPQTKET EAGAEISALV NYVQPVHFSS FENSEKKARF YEMSSFDEKQ
ATTLLKERPI EFVNYNKHQL SRVYPAGTRF DSSNFMPQLF WNAGCQLVAL NYQTLDLAMQ
LNLGIFEYNH RCGYILKPEF MRRKDRRLDP FAESTVDGII AGTVMVTVIS GQFLTDKKVG
TYVEVDMFGL PADTVRKKFR TKIVRDNGIN PVYDEEPFVF KKVVLPELAS IRIAAYEEGG
KLIGHRVLPV IGLCPGYRHL TLRTEVGQPI PLATLFLCIV VKDYVPDGLS DFAEALANPI
KYQSEQEKRS KQLAVLQEDM EPSDEDSCTN KKGDTLRSSE TNNTTSSPAR QRSVAGTQSS
QGGAGGTADS DAEAPLEAIT KMVALPVAQS SSLDHSNVPA AKLSTTSREP TTTGGGGGGG
SGAPIITTTT NTPNVATGEG LNAANGGKIV ADPLEKIFED KQIRKKREAL EKELKALKKS
HDKEKLKIHA AQKSTDLGGG DAPVKKSKFG MGNKLVKRFS SKNMADMNVK VPPCASVSDA
EGTGDAQAER LRQICRDHAG SYREVLEKYH DIIYTLAEDL LRQSQDAQMK QLKTQLERET
SEVMRQLQLS RKSEVKQLAM VHKDKDELER MKREVDSTLV EKGVTERVRL TATYERKRDE
LQRQHDSVKQ GLEDHKLKAR SMLEKEAESH AFISDTFLAH LNTSNSTTSC SSVGATTNHP
PATSVSSGNI CGAGGTAGST HENNVNNAHA
//
