ID A0A3F3QF77_9EURO Unreviewed; 499 AA.
AC A0A3F3QF77;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=BDQ94DRAFT_135110 {ECO:0000313|EMBL:RDH37831.1};
OS Aspergillus welwitschiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1341132 {ECO:0000313|EMBL:RDH37831.1, ECO:0000313|Proteomes:UP000253729};
RN [1] {ECO:0000313|EMBL:RDH37831.1, ECO:0000313|Proteomes:UP000253729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 139.54b {ECO:0000313|EMBL:RDH37831.1,
RC ECO:0000313|Proteomes:UP000253729};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; KZ852034; RDH37831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3F3QF77; -.
DR STRING; 1341132.A0A3F3QF77; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000253729; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:RDH37831.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253729}.
FT DOMAIN 67..411
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 499 AA; 55580 MW; 46E8AA0B25F6C11B CRC64;
MLLRRSICRF STPSSWISRV SPATMPLRAK LTNPAFGATA SMSTAPIPKE LPGDEPDDVL
FHSHYGVRLI ELNRPKKLNS LNGSMVRKIV PRLKEWEKSD LANVIMLSGA GSKALCAGGD
VAALALQNEK GPEGQQASSD FFADEYRLDH LIATYQKPFV SVMDGITMGG GVGLSVHAPF
RIATERTVFA MPETTIGFFP DVGGSFFLSR LDGELGTYLA LTSERLHGVQ ALYAGVATHY
LHSSALANLT ARLSELVFRD YSTFQDRLAL VNKTMAEFST GVPSVREEPI QLAGKLRSAI
DRCFQYNTVE EIIQALQKET EMKSWAEKTL ETLSARSPTS LKVALRQLRV GRQWTISETF
QREHAIASKF MRHPDFVEGV KARLMSKPPR QATWQPATLE EVSTEATDQF FEIPESASGP
ESRLSLYHYK SPYTQYPYKF GLPSESRIEA FVRHRGRKGD LTLKEIVSNF DSKEGVKEKV
AEVLARRTVR DEAGLHWVN
//
