ID A0A3G1LCF7_9NIDO Unreviewed; 2528 AA.
AC A0A3G1LCF7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ORF2 {ECO:0000313|EMBL:AUG33463.1};
OS Dianke virus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Mesnidovirineae; Mesoniviridae; Hexponivirinae;
OC Alphamesonivirus; Namcalivirus; Alphamesonivirus 10.
OX NCBI_TaxID=2060479 {ECO:0000313|EMBL:AUG33463.1};
RN [1] {ECO:0000313|EMBL:AUG33463.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SEN235030 {ECO:0000313|EMBL:AUG33463.1}, and SEN249606
RC {ECO:0000313|EMBL:AUG33466.1};
RX PubMed=28616499; DOI=10.1016/j.onehlt.2017.02.001;
RA Diagne M.M., Faye M., Faye O., Sow A., Balique F., Sembene M., Granjon L.,
RA Handschumacher P., Faye O., Diallo M., Sall A.A.;
RT "Emergence of Wesselsbron virus among black rat and humans in Eastern
RT Senegal in 2013.";
RL One Health 3:23-28(2017).
RN [2] {ECO:0000313|EMBL:QGW51129.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DiankeV_MP_SN {ECO:0000313|EMBL:QGW51129.1};
RX PubMed=31697989;
RA Diagne M.M., Gaye A., Ndione M.H.D., Faye M., Fall G., Dieng I.,
RA Widen S.G., Wood T.G., Popov V., Guzman H., Ba Y., Weaver S.C., Diallo M.,
RA Tesh R., Faye O., Vasilakis N., Sall A.A.;
RT "Dianke virus: A new mesonivirus species isolated from mosquitoes in
RT Eastern Senegal.";
RL Virus Res. 275:0-197802(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KY056254; AUG33463.1; -; Genomic_RNA.
DR EMBL; KY056255; AUG33466.1; -; Genomic_RNA.
DR EMBL; MN622133; QGW51129.1; -; Genomic_RNA.
DR Proteomes; UP000265820; Genome.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd23187; Mesoniviridae_RdRp; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21402; ZBD_mv_SF1_Hel-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR046438; NIV_2_O_MTASE.
DR InterPro; IPR046436; NIV_EXON.
DR InterPro; IPR027352; NSP13_ZBD_CoV-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF13604; AAA_30; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51653; CV_ZBD; 1.
DR PROSITE; PS51955; NIV_2_O_MTASE; 1.
DR PROSITE; PS51953; NIV_EXON; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|PROSITE-ProRule:PRU01298};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01298};
KW Nuclease {ECO:0000256|PROSITE-ProRule:PRU01298};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000265820};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1047..1134
FT /note="CV ZBD"
FT /evidence="ECO:0000259|PROSITE:PS51653"
FT DOMAIN 1791..2058
FT /note="ExoN"
FT /evidence="ECO:0000259|PROSITE:PS51953"
FT DOMAIN 2284..2528
FT /note="Nidovirus-type SAM-dependent 2'-O-MTase"
FT /evidence="ECO:0000259|PROSITE:PS51955"
FT REGION 534..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 1804
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 1921
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 2039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 2044
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
SQ SEQUENCE 2528 AA; 293256 MW; 542A06187DC2697C CRC64;
MLLNQESDLF LIEHKLVHDT IPHLLRYNMT ALSFADLYGL IKEENWHPIY DTLPQVTYHK
INDDLLLKLK SHTPSPQHTC CMLCRRFLVE FGILLHKLNY KVFETTKAML KHYDFVLTAD
NVDLNGILDF EDYKPRKDIY EFDVKSQLRI MQPYYHMLYS FYEHTGMYFI SQPIYTSIVD
PSLDLIQQFE SAVEAIRHLP LDSKFDDQPL YRPTIQHLAK YLKLDLYAME PEPLWNCYDT
MECPQIELAG IDNAVTSIII KPTRPLSEYI ELNHTTVKNF DGDVYCKINH NEINNLQDIL
YNLPLDATIH ELYIVDHPYE LESHNRMLRT SLNIWLHNLY DANVNLSHFD SINYEKTRKA
SFPIVGEIPA ILLRDCEVCK DKIPDDLKDV YDFGSCVHAK AQLSDYKTPR KLHPLIEFDP
ALLRHGEFLP NNDYAYTMKT KPDHLIDREL KEYIDSTGLT ALIPPLNINP AVHDPETTYS
SPYYIKTPSE QSIRQDLELF NQNTAGSVSP TVFLMAIELL HQLLTEEISA SDGKPNCPMV
PSEVPVRNKH KSAGTPYRKF GDSEFMRELY GNYRDAIVYH KRHSADQQLT LTINKVAPSK
NHRDRTILAI SINKSEPGRS LYRWNLDKIK YTSSLGGPIL IGFTAQYGGW DKIYKYLYKN
SPADNPGTAE HAVLGGKDYP KWDRRISNML QLTTTTVLYS LIDPNTQKNL NNATPSQTWH
EYMAETTQVL YDYLVFGNEL FQKPGGVTSG NSRTADGNSL LHLLIDFYAI ISMLIQSTPE
NVHLEEKLRN SLCKTVFTKI PSDYIDPSCV TLRNTDTLHI IRQRVAKGAY LSDDGLIVID
PRIICMFAFM AVSHLISHYM IAQNKNKYHI DAIERYAREF LSQDTIKFGD MVFPIPEFGR
MYTAMLLSDN KNTLDPQINI TRLLALFSYV YIYYFKYVDE PTHPIVKFLD VLRNYIELKL
NTTDEIFLDC IKVPDLQDVE FDLKNCDLYE NFDYLWGLDQ SSAYMDYLCK YKHRYRNLSL
FKRQLIQQHE EAQLRNENML QNKGKLITYN CYVCGENAYL TCATCERAFC NSADTNHGSH
MEQHLQYSGH TCLYLNCKTV KCHHCYTTDI NLLYTTGREH YCESHKPKNA VRILNYNENV
KLPPLLYLCV TDTKRITFYE QCYMNYTKAH PIYAISKEQF MGLIQLYLHQ DYTLPVNQLA
NRIRVSLQLS SYGVVRPYHQ LIMQLTKLES KVLDSSVVDI PITLINSQEI GTYYIEIPRE
HKLDQHSTYS YLMGTREVSF TPNYYRLSST NTHIWQTDTQ IPNYCTFIRQ RRLNTLSAIL
RNTTQHVPEY TRLLLAWNQQ LPITAKPFPE FKPSLKIPAQ PNVTDNINIL LKELNEKRFK
IMFGGPGTGK SHTLSILINH LHEKGMRILV YTPSHQSANA LLYKIAHMMK RRAIQNPGLV
RIVTDGMKEA IKLHPYILYR PNMLDKDRIC VTTIQSFSTV QHVKDIDLVI LDEFSLTSDN
YLLTGLAHLK PSTRVLFSGD PRQLSGVDEI RKPLQSRFHT LINYYTETYP REVHVLKYHF
RCHPSIFQYF KDLYYADKDM ECATSIADRI IRPLNPINTV QVGEPTFRNQ GVILNQDETD
KVLEILVLVN QTLALHASYD YQPTIAIICS YKSQLQNFIS LQQQKILSEN VKLSTIDSAQ
GDEFDIVILC LSQINNFTLN PNRFNVAISR AKSVLFITVP PIDKNPAFLF KDVYETLNKH
NLTYFKIYNT SGKAILSLDS PTTLKTQAEM KYTNVRHLDK NIYTMQRKFP MNIVMDDCIC
FDAEFLNPRD NVQEPVMLSY GFSSKYGKRR IAGIPVRYII DKFDRIVPQK YNYKDNNKPL
TSTYTCDWMR KQQPEQYKHL LTSVMQGIRN DTTVDLKPLL NFCVDNMHVK PVIITWSGAS
DHCFLKAHTL YPDISTVCNI TTRCTSQPIY ASPQGRHTYY LCQYHAHNLK DQLNITHFVN
LEIIDLKVDR NQYTNERTLK VYHNDYLKLT LDLDNVASNS LTDCHARYCR TIHAPITPHD
PLDDAIMTQC IYQSLVLSHL EKLAYEPQAN LKAFTSMDYR LKNFNPEMCK LRRELQKIWY
QQYINTNKTH CNMGCGKEPL KQALHNIDVL QGKSNPQNNM NTHTCDSEEH IYFDSHWYKD
GGFSKPSYIF SDINKEHYYK LGTTGLCLYL NSKYAKYVHE YRTVSGNDVF KSLYSPFCDL
GRKPHQAKIE PSCSIPDCII TSNIGEQFQT LVCNIHIDQM DIISKISQAT KYGYQFIYTG
KTLLNNHAAL AKAPHNWDHL TLEIPGYNTR KQHSSHMTTK ALGILHILQD SMLYTNRKTL
NPNLPVILPG SASYLGDTVL ANEMAKTLKQ TKFIHIDPRL KIDNNTTHHR KTLMEMLDIG
YTTELIISDI HNNTSPWIPE LIAYTLKYLI ETGTLIMKIT SRGATEDVIQ QLEELSKNFT
YVRVCNLNAV TFSSELWIVF ANKRKPPVQG WTSHELRAEL RKHWYSMTRS IIQPLMRSRQ
SVFRYSPK
//
