ID   A0A3G2J9X4_9ACTN        Unreviewed;       459 AA.
AC   A0A3G2J9X4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Insulinase family protein {ECO:0000313|EMBL:AYN39098.1};
GN   ORFNames=D9753_09445 {ECO:0000313|EMBL:AYN39098.1};
OS   Streptomyces dangxiongensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1442032 {ECO:0000313|EMBL:AYN39098.1, ECO:0000313|Proteomes:UP000268329};
RN   [1] {ECO:0000313|EMBL:AYN39098.1, ECO:0000313|Proteomes:UP000268329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z022 {ECO:0000313|EMBL:AYN39098.1,
RC   ECO:0000313|Proteomes:UP000268329};
RA   Zhang B.;
RT   "The genome of Streptomyces dangxiongensis Z022.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; CP033073; AYN39098.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3G2J9X4; -.
DR   KEGG; sdd:D9753_09445; -.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000268329; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851:SF149; GH01077P; 1.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000268329}.
FT   DOMAIN          45..192
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          199..380
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   459 AA;  49619 MW;  BE21C51A8CA5063A CRC64;
     MTSRSSKATA RTSSEARAVA RTQTLVKGTG GIGTVRRTTL PGGLRIVTET LPSVRSATFG
     IWAHVGSRDE TPALNGATHY LEHLLFKGTS RRSALDISSA VDAVGGEMNA FTAKEYTCYY
     ARVLDTDLPL AIDVVCDMLT GSLIREEDVD VERGAILEEI AMTEDDPGDC VHDLFAQTMF
     GNNALGRPVL GTVDTVNALT ADRIRRFYRK HYDPTHLVVA CAGNIDHNKV VRQVRAAFEK
     AGALGNTDAR PIAPRDGRRA IRTHGKVDLL ARRTEQAHVV LGMPGLARTD DRRWAMGVLN
     TALGGGMSSR LFQEVREKRG LAYSVYSYTS GFADCGLFGV YAGCRPSQVH DVLRICRDEL
     DHVADNGLSD DEIARAVGQL RGSTVLGLED TGALMNRIGK SELCWGEQMS VDDMLASIAA
     VTPDEVRSVA RDILGQRPSL SVIGPLKDKQ AARLHDAVA
//