ID A0A3G2JI72_9ACTN Unreviewed; 567 AA.
AC A0A3G2JI72;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Precorrin-3B C(17)-methyltransferase {ECO:0000313|EMBL:AYN42014.1};
DE EC=2.1.1.131 {ECO:0000313|EMBL:AYN42014.1};
GN Name=cobJ {ECO:0000313|EMBL:AYN42014.1};
GN ORFNames=D9753_27480 {ECO:0000313|EMBL:AYN42014.1};
OS Streptomyces dangxiongensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1442032 {ECO:0000313|EMBL:AYN42014.1, ECO:0000313|Proteomes:UP000268329};
RN [1] {ECO:0000313|EMBL:AYN42014.1, ECO:0000313|Proteomes:UP000268329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z022 {ECO:0000313|EMBL:AYN42014.1,
RC ECO:0000313|Proteomes:UP000268329};
RA Zhang B.;
RT "The genome of Streptomyces dangxiongensis Z022.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; CP033073; AYN42014.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3G2JI72; -.
DR KEGG; sdd:D9753_27480; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000268329; Chromosome.
DR GO; GO:0030789; F:precorrin-3B C17-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AYN42014.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000268329};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AYN42014.1}.
FT DOMAIN 36..116
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 191..312
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 320..525
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 567 AA; 57888 MW; 16613101E2AB7C6C CRC64;
MIGLISATAA GAAARDRLAA AWPDRTRVYD GPVGEAVRAA FAECEQLVCF LATGATVRLL
APLLGDKATD PGVVCVDEGG RFAVSLVGGH GGGANALARE AGELLGAEPV VTTATDAVGL
PGLDTLGLPY EGAVAAVSRA LLDGEPVALE AEVAWPLPPL PLAARGAYTV RLTDRAVEPG
EREVLLRPPS LVVGVGASKG APAEEVLALV GEALREAGLS PRSVAELATV DAKADEPGIL
GAAERLGVPV VTYTAGELAA VEVPNPSAAP LSAVGTPSVA EAAALARGGE LLVPKRKSVR
ADGRPAMATC AVVRRPGRGR LAVVGLGPGA RDLLTPRAAA ELRRASVLVG LDQYVDQIRD
LLRPGTRVLE SGLGAEEERA RTAVAQARAG HAVALIGSGD AGVYAMASPA LAEASDDIDV
VGVPGVTAAL AAGAVLGAPL GHDHVSISLS DLHTPWEVIE RRVRAAAEAD IVVTFYNPRS
RGRDWQLPKA LAILSGHREA TTPVGVVRNA SRPDESSRVT TLGALDPATV DMMTVVTVGN
TATRNIAGRM VTPRGYRWQN GTQEGAR
//
