ID A0A3G2LB84_9FLAO Unreviewed; 384 AA.
AC A0A3G2LB84;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:AYN69514.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:AYN69514.1};
GN ORFNames=D1013_20095 {ECO:0000313|EMBL:AYN69514.1};
OS Euzebyella marina.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Euzebyella.
OX NCBI_TaxID=1761453 {ECO:0000313|EMBL:AYN69514.1, ECO:0000313|Proteomes:UP000276309};
RN [1] {ECO:0000313|EMBL:AYN69514.1, ECO:0000313|Proteomes:UP000276309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RN62 {ECO:0000313|EMBL:AYN69514.1,
RC ECO:0000313|Proteomes:UP000276309};
RA Xue C.;
RT "The reduced genetic potential of extracellular carbohydrate catabolism in
RT Euzebyella marina RN62, a Flavobacteriia bacterium isolated from the hadal
RT water.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CP032050; AYN69514.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3G2LB84; -.
DR KEGG; emar:D1013_20095; -.
DR OrthoDB; 9803729at2; -.
DR Proteomes; UP000276309; Chromosome.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000276309};
KW Transferase {ECO:0000313|EMBL:AYN69514.1}.
FT MOD_RES 200
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 384 AA; 41910 MW; 3974D27FE3B2C3A7 CRC64;
MDENSLKFNS RTIHGGQKPD KAYGAVMPPI YQTSTFAQSH PGGHQGYEYS RSGNPTRSAL
ENSLASIENG NYGLAFASGL AAMDAVIKLL KPGDEVISTN DLYGGSYRLF KKVFEKYGIT
FHFVGMQDVL NIEAAITPKT KLIWVETPTN PMMNIIDIKR VAKIAKKNRI LLAVDNTFAT
PYLQTPLDLG ADLVMHSATK YLGGHSDVVA GALVVNDKAL ADELYFIQNA SGAVCGPMDS
FLVLRGIKTL HVRMQRHCEN GEAIANFLRS HSKIEKVFWP GFENHPNHQI AKEQMQGFGG
MISFVTKGNN YEDALKIVSN LKVFTLAESL GGVESLAGHP ASMTHASIPK EEREKSGVVD
ALIRLSVGIE DVNDLIADLN QAIE
//
