ID A0A3G3GST6_9BACT Unreviewed; 1091 AA.
AC A0A3G3GST6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
GN ORFNames=DTQ70_20290 {ECO:0000313|EMBL:AYQ34353.1};
OS Runella sp. SP2.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae; Runella.
OX NCBI_TaxID=2268026 {ECO:0000313|EMBL:AYQ34353.1, ECO:0000313|Proteomes:UP000270973};
RN [1] {ECO:0000313|EMBL:AYQ34353.1, ECO:0000313|Proteomes:UP000270973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP2 {ECO:0000313|EMBL:AYQ34353.1,
RC ECO:0000313|Proteomes:UP000270973};
RA Jin H.M.;
RT "Genome sequence of Runella sp. SP1.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
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DR EMBL; CP031030; AYQ34353.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3G3GST6; -.
DR KEGG; rup:DTQ70_20290; -.
DR OrthoDB; 9815657at2; -.
DR Proteomes; UP000270973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 3.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Reference proteome {ECO:0000313|Proteomes:UP000270973};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}.
FT DOMAIN 719..786
FT /note="Tricorn protease C1"
FT /evidence="ECO:0000259|Pfam:PF14684"
FT DOMAIN 821..878
FT /note="Tricorn protease PDZ"
FT /evidence="ECO:0000259|Pfam:PF14685"
FT DOMAIN 910..1063
FT /note="Tail specific protease"
FT /evidence="ECO:0000259|Pfam:PF03572"
FT ACT_SITE 781
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 997
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1054
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT SITE 998
FT /note="Transition state stabilizer; via amide nitrogen"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-3"
SQ SEQUENCE 1091 AA; 121687 MW; 6D78F8C99820342C CRC64;
MNTFLSTLYQ PFSQTTLLVK KNILLLTIFF LTSALSQALF AQTWLRYPSI SPDGKTIVFT
YKGDIWKVAA SGGAAVPLTL HEAHDYMPVW SHDGKRIAFA SDRHGNFDVF TIPAEGGEAK
RITFHSANEL PYDFSTDNQN VVFGSARQDL ATNRQYPAGY MTELYSVSIN GGRVKQLLTT
PAEDVKYNRD GSKFVYHDRK GGENAWRKHH TSAIARDLWV YDTKTQKHTK LTNFAGEDRN
AVWSDDKTLF YLSETSGSFN VHKLSLDNTA QSQAITSFKK HPVRFLSRAN DGVLCFGYNG
EIFTLNPTEG GNPKKVNISI AADTRANNDR VLSVNGGVSS MAVSPNGKEV AYIFRGEVFV
SSVEGGITKR ITNSAGQERS VSFSPDGKAL VYSSERGNRW KIFETRISRK EEPYFYASTL
LKESELIANE KENYLPKYSP DGKEIAFVED RATLKILTLA TKQTRTILTN QDLFSWGDHD
QYFQWSPDGK WFLFDYKIPN LREGEVGLIS TDGKGKITNL TQSGFEDESP KWVQGGKAML
WFSNREGLKS LSQSGNTQSD VYAMFFTQAA FDKFKLSKEE AALAKEVEEK AAKADTTKKK
DAKKDSTVVI ELDGLELRKA RLTIHSSNLS DALINKDGDM LYYLSRFEKG YNLWSTNLRT
RETKQLVALN ANGGGSMVWD KEQKSIFLNS DGRISKIDPT SGKQESIGIS GEMNLDVAAE
RAFMFEHVWR RTKTTFYTAT FHGVDWDSYK PDYEKHLPHI GNNYEFSELL SELLGELNVS
HSGASYFGGG TAGADATAAL GVFYDQSFTG TGMRVEEVIK DGPLDKAGLN IKAGTIIEAI
DGETLTPDRD YAQFLNRKSG KNVLLTLLEG TARREVVVKP ISVGEESQLL YKRWVRRNQD
EVEKQSNGTL GYIHIPGMAD GPFRVTYDEV MGKYALKKGI VVDTRNNGGG DLVSDLATFF
SGKTYMYNST DKRVIYSEPS YRWSKPSISL ANEANYSDGH CYAHMTQAAS LNKLVGMPVP
GTCTFAGWET LQDPSIRWGV PPVGVKSMAG TYLENAQTEP NIKISNDYDI VGKGKDQQLE
RAVEELVKEV K
//
