ID A0A3G3ILW6_9GAMM Unreviewed; 7303 AA.
AC A0A3G3ILW6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Peptidase C80 domain-containing protein {ECO:0000259|PROSITE:PS51771};
GN ORFNames=MS2017_1064 {ECO:0000313|EMBL:AYQ56771.1};
OS Bathymodiolus thermophilus thioautotrophic gill symbiont.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; sulfur-oxidizing symbionts.
OX NCBI_TaxID=2360 {ECO:0000313|EMBL:AYQ56771.1, ECO:0000313|Proteomes:UP000278334};
RN [1] {ECO:0000313|EMBL:AYQ56771.1, ECO:0000313|Proteomes:UP000278334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EPR9N {ECO:0000313|EMBL:AYQ56771.1,
RC ECO:0000313|Proteomes:UP000278334};
RA Won Y.-J.;
RT "Genome sequence of the bacterial symbiont EPR9N from a vent mussel
RT Bathymodiolus thermophilus.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytosol
CC {ECO:0000256|ARBA:ARBA00023586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; CP024634; AYQ56771.1; -; Genomic_DNA.
DR KEGG; bthg:MS2017_1064; -.
DR Proteomes; UP000278334; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd20900; HopBF1; 2.
DR CDD; cd20500; Peptidase_C80; 4.
DR Gene3D; 3.40.50.11050; -; 4.
DR Gene3D; 3.90.550.20; -; 1.
DR InterPro; IPR020974; CPD_dom.
DR InterPro; IPR038383; CPD_dom_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR Pfam; PF11713; Peptidase_C80; 4.
DR SUPFAM; SSF51120; beta-Roll; 2.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51771; CGT_MARTX_CPD; 4.
PE 4: Predicted;
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host membrane {ECO:0000256|ARBA:ARBA00022511};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 3868..4056
FT /note="Peptidase C80"
FT /evidence="ECO:0000259|PROSITE:PS51771"
FT DOMAIN 4380..4567
FT /note="Peptidase C80"
FT /evidence="ECO:0000259|PROSITE:PS51771"
FT DOMAIN 4867..5059
FT /note="Peptidase C80"
FT /evidence="ECO:0000259|PROSITE:PS51771"
FT DOMAIN 6150..6334
FT /note="Peptidase C80"
FT /evidence="ECO:0000259|PROSITE:PS51771"
FT REGION 1022..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3032..3062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3636..3693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3842..3876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6361..6402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6414..6440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6812..6858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3857..3876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6370..6396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6821..6835
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7303 AA; 797406 MW; 4CCE598DDDD7A2EB CRC64;
MGSVVNIFRS VVDSIVYFVT GSYVGDDGDN TLTALGFAVW GDGVYMHGGN DTVYAASLKL
DVYDTWGDLS IYGAAGLMNI NKSDWGNMSV TGLSGAMTLR HTGRSGNINF DGAAASNDVY
RHGNTGNISF LGIGISNRVI NDVKYGNIDF TGAGMSNVVE RRGGERGTIH FKGAGALNKV
TNTANQGNIY FSGIGAYNKV ERRGISGNIV FTGAGFYNKV TNITHQGNIN FRGIGGYNKV
ERRGGYKGNV FFKGVGIGNH VINTAEYGNT DFIGGGGANV VKHSANGNLS FKGIGIINKV
DHTGDYGNMT FIGGGGGNFI TRSGIKGNGD LTILGGGNIV TWSTDGKLKA KLGGFRLNKI
DRYGRGDTNL ILISLGNIVN VDVSKGDLSL TGIGIANIVT YKGHGTLSAE LFGGANIITR
EGTGDSILHL LAGANVFTDF STGDISGSLL GGLNVVTKDG NGDINISMYG GGNVLTHIGD
GDIQTRMLGG ANVITKSGNG DIIALLFGLA NVVTHIGNGN VYLLMLGIGN IATKVGDGDV
IVGMFGTGNV LTHVGNGMTA ALMISTGANF FTKVGNGATL AVMFSLGGNI FTHIGDGPSA
VLMIGGQANI FTKIGNGASV AIMLAGTANV FTHIGNGFSA ALMIGGCTNV FTKVGNGTTL
ATMIGGGNIF THIGNGFSVV FAVGEANIVT KIGAGNLITA AIGQANIVTH INLAGSSDGN
TVSLVIGQAN IVTRISSLAD FSVTVSPLDA IVSDPVLERH RLFPRGDIFS APQKFLESGF
DALKATGAAL LGSNNEGSMV TFAVGRANII THVGNGAMLG VGIGDANVIS KVGLGQTIQA
GIGRLNILTS VGDNDSLQIG IGEGNLITKV GSGHSAMVAI GKANITTKVG DGFHVGLSIG
KFNVNTLVGD GIAVNALIGK YNLNTRVGHG VNVAVMKGDY NINVRYGDGM NVALAAGKGN
ITVKIGDGDF YGAMIEIRTN KQSVTAKMKA LMQGMLSNLK ETAKSVLVSQ TIGTVINGDE
ADTTKLRGTS HSTPKTKTEY TQNVNSANKD IDQSQYQDTD ANEDSDIDTQ SSKDKQTVNT
LKSDTRVNEE DANHDAQTVT AFLNNNNNSL IPTQTQSQGQ GQGQSQTHST GLDELNQSGQ
SDYHNSYTQF GNTDKITNGA NQDIENSKGG IDKSKSKTQQ ELNNVKQRNQ KNQLHQQKEQ
QGASQRLGDA HLKNQEIGSK AIKQKGPALV AMKVYPTSQH PATKSVFEIG DKVMIALTMD
RAMKYQEGKA KYAADSKVII NGLVFSLCAN KGFADPSTNP DEITVKNTQL IFEHTVQIND
AFTQGKSFAI QSFSDLIISG ISDNDGYPPT FTNIIYPISL NNTIATKFDQ RNLSVSGNTF
QGYTISKESS DASWNTDAFS QESFVGDGYA IFTLNATSAR KGLMLGLSTD NPDGSYKTIE
HAVFIHNNKI KDVRNNNTKY TDLNYRYQAG DQIKIERHGT TIRYYHLDHN GNTLRILATQ
TGISATSALH IDTSIKDKNL TLTHVKLVKG LSNISPYTID VHAPKPIADA WHIKGETSNT
DNTDNTNNIL TIGDKIKVTL ILNEAVTLAK VGSNKIMIAG KAFLLTGENN TSTNTLEFVY
TIQANDTIGT KDFNIDNQYD ITLTDVKDTD GNNIDFSSIT SPIQFSKTSL DTNFDIGGGN
RITRTNDTYE KTSGAGWNAD VTSAKGFVND GYVIAKIGAL GKSMMLGLSS GDTDNSYGSI
DYALYADGGI GSKFVIYENG DRKKDTGVAY AIGDYMKVVR SGTSIKYYHI KAADGPLAKG
TLLYTSKKTS NANTQLFLDS AFLSVGAKLS AMQIFSNNHL PFSVDVYAPK PISTNAWQID
TTTADNNGVF TLGDKIKLTL TIDEAVTLAK VGSNKIMIAG KAFLLTGENG TVTNTLVFTY
TVQINDKIDA QYFNISNKND IILNNVTDSD GNNINFDSIT YTTPVKLSNT SLDNNLTISS
DKRITLTNGV YEKTTNAGWN SDVTSTKGFV NDGYVIAKIG ALGKSMMLGL SSDDTDNSYG
SIDYALYADG GIGSKFVIYE NGDRKKDTGV AYAIGDYMKV VRSGTTIRYY HIKAADGLLA
KGTLLYTSSK TSNANTQLFL DSAFHSIGAK LSEMQILSGN KPTLSVDVYA PKPTTNAWHI
DCEPANSKGI FTIGDTIKAT LTLDKRVTLA NVGRNKIVVA GKEFLLTGTN GTVTNTLDFT
YTIQANDKLI ATSMRYDVLL TGVVDDKGNS VDMSNATSPV GLSNKLIDTD LVINTKPLIA
SFHSFVLPNL STITHTDGVY EKILASNWNT NITSAKGFTN DGYAIAKIGS LGKHMRVGLS
SVNTNNSTHN MDYALYVSDN TFLIYEKGHY KKDTQVSYAV GDYIKIARSG STIKYYHIKA
ADGALAKGTL LYTSNNTSNA NTQLFLDSSL YGAGAKLSNM QIFSGSHVAF SVDVYAPKPT
KDAWHISGTV NDQGAFALGN EIKITLNIDE AVTLAKVGSN KIIIAGKEFL LTGTNGTVTK
TLEFAYTVQL NDKINSAFLI DNKDDIVLTD IKDTDGNSID FGNLSNGIDI TPNSQNLALN
NKGLATITTN ITRWYANNTN SNIQRMTDGN TRANGALDYA THPKNADGKH ILFDFKGVNY
NNGSFKLYNR KILTSRINGS VVEFLKDGVV VSIRTISDAG NVIEITPSSD IVFDQVKLTF
NGDLQNFREV EIFGKNASLS IDAGAPEPLK HNAWRINRDI ADSGGAFTVG NEIKVTLRLD
EAVTLAKVDS NKITIANKDF FLTGTNGDTT KTLTFTYTVQ ANDNINAEDF NINSKKDIVL
NDIKDTDGNN INFSSITGAV SLANASLNTD FVIGGNNRIT HINGVYKKTA NANWNADVAS
TKGFVNDGYV IAKIGASNKK VMLGLSSNNS NNSYDSLDYA LYADPGTNKT LIVYESSERI
YCTGVTYAKG DYMKVVRSGT SIKYYHIKAA DGPLAKGTLL YTSKKTSNAN TQLFLDSAFH
DVGATLSEMQ IFSGNYSALS IDVHAPKPIT NAWHTNSIPN NNSTNDNDNN DNSDNNTKKS
KNISKGVFTL GDQIKVTLTL DKRITLANVG KNKVIIAGKE FLLTGVNGKI TNILEFAYTV
QVNDKIDTAF HINNKNNDIV LIDIKDTDGN NINLSKVPNS IDIIPNIQNL SLSKQGLATI
STNVSSWYTD DAATNIQRMT DGNTSASGAL DYATHPMYAD GKHILFDFGA ANYSNGSFKL
YNRESFTNRI NGSVVEFLKD GVVVLSRTIS NAGNIVTITP ATYVIFDQVK LTFSGDAQNF
REIEIFGKNS NLSIDSGAPE PLKNNAWHIN RDVADSNGEF NVGDEIKVTL TLDEAVTLAK
VGSNKIIIAN KAFFLTGTNG TITNTLEFTH TVTINDQINA KDFDIDNKND IILIDVKDTH
GNNINFSNIT RSIELANIPL DTNFNINNSN ANDNNNSNNI IHTGNLYEKT ANTGWNTNIT
SAKGFTDNGS VIVKIGSNNK ALMVGLSTNN NSDSNNNNND NNNPTTSFAI HINNTGNINA
VYENNQCVKE FPTDQYLYSA GDYLKIERDN TTINYYLIKA NDQATKGTLL YTSSQILSAN
TKLFSNSALH DIGAQISNIQ MFDDNKSSLS IKAKMSTSTT NPLGDNDTFD QTSGNYQLNN
NSRTGTSTNN NNPNNPNNPN NPQNTQEEQN TQTAQKWFKP TINHHFFQNL PSPQNLPSSQ
APQIFIITGL SNANVDLAMQ LKTKHDIVIY YNTTTNQIEY LYGQENDIEV TRIEYHIIAN
GKSINTLVED TLNNTYTVNT DDDPDDDIDT QAIVAQLQQA ITTNRANTRL HANWLTRHSF
AKRGLPFTPT PTTPNTQPST QPNTQPNPQS TQKTSKYQSN IIVQNSNDPT VIEAANALFN
KHPTTSILVK FDQNGNLITL KGAPYTPTGD TRINFVDHGT NLSQEGAQSL ANKAQTLHQT
YSNSNTNIKR IALVGCSTDG ANQDLTRNFA KTIYNNTPAL KSAEITGRHG DIQINPDGTK
TMVVGGEKMI YQWNADLDIV TQQTEESKRV AEVLSGLKLG GASSKGASDT IDIDSIPNTL
TSKEVDTRFP IGSGMYKTAY DIENQPDLLV LLLEPSCRVY DIEEEARMLE KLDSLGVKTP
RRYKQIKFVD EANDGTKTER HGLVVQKIKG AQDMKLTRKR WIFGNKLRKA LKNSNDKTLK
DIEHLQKIFA KNPTLSVSDF QGLVAEDGQF YIIDPLSIDM SPTNSGNNAT QSDSLQTFER
HILQHHKRFT DKKLKHITYV DKQLWKSPDN TLKQQMLSDA QENKNRVIVT YDIATGRKEV
VHQPSNSQNL AFNTVEVIAR DNKNQSANLE KECLDFARKQ GWKQSNNSIF RVNTLKGYEA
LNLKSNGKNK YNIILSIGED EITKNAVESL YKKHPENSIV VTLNEQGELV FPGGQEFIPD
SSVRINIVGH PEELEKVGAE KLANYTDGIA QHYDIDSVDS HAYLNRAALV GCNNEDLSKR
YAEQLYTREY LRGASVTGRS GDMQINADGS KTMSSSDQKI IHSWDYEDNK TVWATESSAH
IGEILASLKL GLSDTPSTDI PDSLNYNDIG KEVSKGSMKT AYTLKDHPDL LFLQLDAKAS
IKVDNLENEV AWINKMRELG IKTPKYYKTI VMTDQNQQKH QGVLVERIPD SKLVRPNFAT
TMKTERTTKR TLDDIQNLLD KFAQNPDLYI PDFQMLMGED GQLYVFDPGS AKPPMALPDS
PGHQGVRRMN VIGLKELNKK ATIFLEKFNK NNRMHAIFVD EASLKKDPKL KDKLINKAKK
QQDLTIISYN LKSALAGTTV LYQPDNPQPI DRIEVMTDKD IRPPSQLDMS FLTQDMSSVS
NDMMFRYKPV KSFSNYRTNI IVQHGNSDTA IKAAQDLANK HPDNSIIVHF DANNKLVTAD
NELYTPNGNV RLSFVDHGEN FVTDESGMDE LVDKVKQIND TYGNENTYFE RIALVGCDTN
SVRKGLTKDF ARAVYNNIPT LRNADITGRT GEVQVNDDGT KTMKTGGAKT VYSWRNGDIV
SETEGAKTTA DKLKNPLSLT IFDFISERIY ELESPTAPAR TPAESEFHRI LFGCRNYVDA
FDYKDMSAQE KISFFKGVKE KLSNFSNTGT PPPSMQAHIA TFESYVEEVI SRNEHRIEMN
EKFPVNITKG NKIPDIIHYV WTGGVISERY LDNIKAIKRQ NDKLTVRLHY DPDSLLMNEL
KKRMQTHVNN NLTVGGNRRY EAIKLTKRFS DYCGDHDLSS DIIKGFMVDV LGVPIAEVNE
IEEKSNKYWG DFPGDNPNLE LAPISFDDTE LPGMKEAYQF ELKNGSMAGA SDVVRFSVLH
TEGGMYADVG LLSNRFNQDN FLYDYIQKFP EDGFTYQQTV DSLHSSYPLA INNNFLVAAP
HSEFTGTLVQ DISEAYNRIT SNEVEQARRG YGSNQVLDQY NTSIVQLSKF YLDHANRLSL
KPLEKHILDT QGSWQSSWNT RGIEFIVFIA DTEKLTPTQR RAFVDHIEKN LDGYNNDAYK
IVVLDSHAVI DPIRRGIIEH MNPFFTIQGV PLKGDGISID YPALFERSRQ IVVFDDNNNF
EPMLTDFNDT VERKEPSKFN KAIEDVVNAR CFQVFLFDDR ANFKRTIQEL APDISRKNYV
ALVYDKSNQR YDVLDDHNFE FKDGDRLKVN FIGELNDLDD LAEIQGKISS AENALPQIDI
KKHATETRVV LSKDMRPDQS LFKIQKTFSE GPDFYTNKGT VAIHAQNNED KSNVTILVNN
EVGRIAIQGN ETLTWPTLEE SQRTSLQGIE NGADKSDNDS LNKYHNIVIQ SSDSWSLASY
HLASDSHLKG DTSIVQVSEN GFRTIYGTPL SLITGDVRVG FTFDDSVDIV NNISSISKTL
GPNVKIKDIR LINRMKIDEL RKAKTQMLYV EEVSRVANRY KDAQVNMQRN MKTDNYLLRN
YSFDLPYAPK FPRIPERNII FKISNDSSVD KYANVMTMMN PNDSYIAILN PATNEVRVYD
SYGNIVTDAN IQGGYEVHVL GRVSDLKRVG SEGVSNHIIN LQKSIKVRPE REVTIRLTPC
STKDSAAGDL SFIPENYTRN IARKLSRYNQ NIRVANMNTN LVLYTNREGV ATAIPNEVHL
AETTPHQDTP IHNWADLSQE QINKLTTEAQ KPQPSLANHD HQVLIQTEAD GNVRDSTFRL
ASKHPAQTTI VQMQKDGTHQ VVYGLDLEDI TGKVKMVAVG YGREKDGTQT MGGRTADELS
ANITELNRAL AGNADIQRIS IVGCNMESDN PTDNNDSQYG RRMVEKLSQS NIKAPVAVRS
SYVAVDENGR KLTSNTGAGN WMHKDSAAKT VYSLGATGAV VSRVYNDEGT LIKYNGRRLN
EDLDNDKSAQ GTENQETSDK HAQGQGQGQG QSESETETTK QKLDDIDKRQ TDFANSVNQN
KLRRLPNGNA PANNDNENTK TGGMSAPALN VQIDIGGGDH ASLFGGSTNV DVKVGNGAHH
TLMYGSNNVL VSIGDIGDSS RFVEIGGYRA LEGVQILIGT KNVVVNHGVR NDLIIATDPS
FPMIPFVNPF DGSANILGSL QGMADISNSG QNALWSWKKT KKFATSMSSL DRTSDTNYEK
ILISGGQNAV SDRGLKYDIE MALNKQANNF MQRESKRQQA KQNFKEHISN FSLNLTIGGQ
GSDILIGNGN FSFMFGDTFS SVLDTTVASL FGIMQQGYTL DGQPKTTFTY TPSNVKTKLI
NGILNGMASQ AKDITFGDIL GYKYTNFGHI YKAVANTPDL SLSNLLKELL GTVSDTFSNS
ITALSEPERI VKALVAGGES FKDMGENTLD ALGIKDKDKD DDDDNNDDDN NNDNDENNKD
ENNNTNTGDN DSESKKNKSN KAFGFSGLKL PSLFNMFTPN LIKTLSSLPE LAETLSSSIS
TDSANIKDKA LELFSDIGFM SNDGDLFFNI GAQNFAWGGD GKDLFALMGT NNNVWGGKGD
DVAYVIGEGN TISGNQGDDS AVYVGQNHMF IGGEGDDIGV ASGRYNTLFG GTGRDQLWAF
GEGAYITGNE GDDYLVSTGN YGKIHGHTGD DIGILIGAHN VMDLGKGNDH GKVFGNKNIV
YLRDGNDELE VASHQSSIMA NAGDDSLYMH KNSSDNKIDA GSGDDLLYLG GTENKVTGGT
GADIFIVGND NIFSTIITDK DDYIAFDLDS YQDTMYYKSN NNLLIKHRSL IKPNKADSDY
QSDNTGVDIA KQYRNQEGSV LIEDYFANSN SNESAKICIS IDTNNDRYHY LDKAQISKLV
EYMSSFDSFA DTEGVANYKR EVNQLWSGAK VGYNMPEVMK SLA
//
