ID A0A3G3JSU9_9BACL Unreviewed; 347 AA.
AC A0A3G3JSU9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sensor histidine kinase {ECO:0000256|PIRNR:PIRNR037431};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR037431};
GN ORFNames=EAV92_01080 {ECO:0000313|EMBL:AYQ71305.1};
OS Cohnella candidum.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=2674991 {ECO:0000313|EMBL:AYQ71305.1, ECO:0000313|Proteomes:UP000269097};
RN [1] {ECO:0000313|EMBL:AYQ71305.1, ECO:0000313|Proteomes:UP000269097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=18JY8-7 {ECO:0000313|EMBL:AYQ71305.1,
RC ECO:0000313|Proteomes:UP000269097};
RA Srinivasan S., Kim M.K.;
RT "Genome Sequence of Cohnella sp.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR037431};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR037431};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR037431}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP033433; AYQ71305.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3G3JSU9; -.
DR KEGG; coh:EAV92_01080; -.
DR Proteomes; UP000269097; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR017202; LiaS/VraS.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR PIRSF; PIRSF037431; STHK_LiaS; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037431};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR037431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR037431};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037431};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037431};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000269097};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037431};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR037431}.
FT TRANSMEM 18..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..123
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 150..344
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 174..201
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 347 AA; 38802 MW; DD74A31658D79DF5 CRC64;
MESRKVANMV WRQMGESVLY SLGIGALVIY LVMRYGIASE VYKWSSVVPF ILTTIGVLTI
GGAAFGFLRG YPVRHRLRLL SDVMLLLEKG NPSPPLPPLG NDEIGRLGEQ LGKLGRKWEE
QVTTLQRLSS NNTELEAKAK MSAVVEERQR LARELHDAVS QQLFAISMTA TAVSRTLEQD
FDRAKRQIEL IEEMASVAQS EMRALLLHLR PIHLEGKRLS QAIPELVHEM KAKVPVDISL
DMEEDLPLNK GMENHLFRIV QEALSNTLRH ARATKMGIEL QRRGDAVRLG IRDNGVGFDV
QERKQASYGM MNMEERVNEL GGSFHVVSAP GKGTRIEIRV PLMADGG
//
