ID   A0A3G3JVJ3_9BACL        Unreviewed;       378 AA.
AC   A0A3G3JVJ3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:AYQ72246.1};
GN   ORFNames=EAV92_06490 {ECO:0000313|EMBL:AYQ72246.1};
OS   Cohnella candidum.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX   NCBI_TaxID=2674991 {ECO:0000313|EMBL:AYQ72246.1, ECO:0000313|Proteomes:UP000269097};
RN   [1] {ECO:0000313|EMBL:AYQ72246.1, ECO:0000313|Proteomes:UP000269097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=18JY8-7 {ECO:0000313|EMBL:AYQ72246.1,
RC   ECO:0000313|Proteomes:UP000269097};
RA   Srinivasan S., Kim M.K.;
RT   "Genome Sequence of Cohnella sp.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP033433; AYQ72246.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3G3JVJ3; -.
DR   KEGG; coh:EAV92_06490; -.
DR   Proteomes; UP000269097; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000269097};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          26..141
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          189..257
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   378 AA;  41172 MW;  38D6763B17069955 CRC64;
     MKAVTFQGIK NVQVKEVADP KIQKKDDIIV RLTASAICGS DLHLIHGMIP NMPQDYIIGH
     EPVGIVEEAG PEVTSLKKGD KVIIPFNVAC GQCWYCNNHL ESQCDNSNPH GDSGAYFGYS
     ETTGGYPGGQ AQFMRVPYAN FTPFKVPESN EIEDEKLAVI ADAMTTAFWT VDNAGVKPGD
     TVIVLGCGPV GMFAQKFCWL KGAKRVIAVD YVDYRLERAK ARNNVETVNF EKEENIGNHL
     KEITKGGADV VIDAVGMDGK MTPMEFLASG LKLQGGAMGA IVIASQAVRK GGTIQITGVY
     GGRYNAFPLG DIFQRNITVK TGQAPVIHYM PHMYELVASG KIDPMDIVTH VIPLDDAKRG
     YEIFDDKLDN CIKVVLKP
//