ID A0A3G3M0E4_9CAUD Unreviewed; 590 AA.
AC A0A3G3M0E4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=8 {ECO:0000313|EMBL:AYQ99922.1};
GN ORFNames=PBI_MENDEL_8 {ECO:0000313|EMBL:AYQ99922.1};
OS Arthrobacter phage Mendel.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Anjalivirus; Anjalivirus mendel.
OX NCBI_TaxID=2484218 {ECO:0000313|EMBL:AYQ99922.1, ECO:0000313|Proteomes:UP000267434};
RN [1] {ECO:0000313|EMBL:AYQ99922.1, ECO:0000313|Proteomes:UP000267434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Rimple P.A., Stoner T.H., Garlena R.A., Russell D.A., Pope W.H.,
RA Jacobs-Sera D., Hatfull G.F.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; MK016500; AYQ99922.1; -; Genomic_DNA.
DR Proteomes; UP000267434; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 3.30.1770.10; TPR 1 domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF03175; DNA_pol_B_2; 2.
DR PRINTS; PR00106; DNAPOLB.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 73..168
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
FT DOMAIN 179..478
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
SQ SEQUENCE 590 AA; 66581 MW; FE2F3C5C40EC79F0 CRC64;
MRFIPAFLAR FVGAIMGGRK QAQYVADFET TTDPDDCRVW AYGLANINTA DSLWDVEIGP
SIHRFFDRMA EEDSVCYFHN LKFDGEFIFW QLFKEGYVHV KDRPHRAGQF STLISSMGSF
YSITVRWKNG KKTEFRDSLK KLPYSVAVVA KAFNQPEQKG DLDYTAYRAP GHIPTAAERA
YIAADVLIVA RALKTQFDQG MTKLTVGSDS LAEFKKLTGT RLYDKLFPVL PDEMDAEIRA
AYRGGFTYAD TRFRGRVTRG GITYDVNSLY PSVMYDRVLP YGEPIYAPGL PSPTREYPLF
IVSLTFTAKL KPGHIPCIQV KGSSHFLATE YQTEITEPVT ISCTSVDLQL WEDHYDLDIL
SYNGGWLFRG ASGFFTDFID KWMDVKANND GGLRALAKLQ LNSLYGKFGT NPNVTPKEPV
YDPDTNTVRL VLGDEETKDP IYTAMACFVT AYARDVTIRA AQDNYPHFAY ADTDSLHLLI
DDDPIGLDVD PHKLGAWKRE YRFEAGLFVR AKAYIERLPS PTHDPEDCPL DRHGEHCRHV
THVAGLPDRI GAYLTIADFK EGNRFTGKLQ PKRVPGGIVL EDVGFTMKMS
//
