ID A0A3G6V9C9_9CLOS Unreviewed; 2191 AA.
AC A0A3G6V9C9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=ORF1a polyprotein {ECO:0000313|EMBL:AZB50206.1};
OS Air potato virus 1.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Closteroviridae; Ampelovirus; Air potato ampelovirus 1.
OX NCBI_TaxID=2491018 {ECO:0000313|EMBL:AZB50206.1};
RN [1] {ECO:0000313|EMBL:AZB50206.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=APV1-FL {ECO:0000313|EMBL:AZB50206.1};
RX PubMed=30460477;
RA Dey K.K., Sugikawa J., Kerr C., Melzer M.J.;
RT "Air potato (Dioscorea bulbifera) plants displaying virus-like symptoms are
RT co-infected with a novel potyvirus and a novel ampelovirus.";
RL Virus Genes 0:0-0(2018).
RN [2] {ECO:0000313|EMBL:AZB50206.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=APV1-FL {ECO:0000313|EMBL:AZB50206.1};
RA Melzer M.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; MH206615; AZB50206.1; -; Genomic_RNA.
DR Proteomes; UP000297067; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000297067}.
FT DOMAIN 695..888
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 1853..2189
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2191 AA; 244406 MW; 62DA0B6BE0447EFF CRC64;
MSKKGHLAPG KLAHLRSNKP KAFLSKPKMP EEGPVAFAKL SAERRKALFF QWISPAEYVP
EHLRRSRATE ARENMMRARK NFSRYHAPNL HLHSANNLCK SAGSYSGLKY YRTSTSFRSN
PEYVRRGHYY VNPRCDHPAS PLVNLAYLRA RYVLTSSTVK GTSFKGVKAQ EVPTYHSKNP
ATLHAGLYNT RTSKSGTSGK SSTKSTKSSG SIPEVVRQAQ QVVAEWRLKS AGKSTSSKVV
RNGRPLDLSA GEGCGRRPFA PVKKTSVQLE TTPAPKKPTK IVKKWVVKTS ETSTSPRSTS
RSTSDGESSL VTRLATEKVR AWQAGQPATS SDLKGKAVLT PQTTQKMSLP TLSSSSGSRG
SGDLRYKNAS TVSTASTNSL QRKLAPMFTS STPDNYMAPI HRRKDTLPLT VERQLNHSSL
EFLDSAPQTT QQFVEHLIAE GELLTLGKRC FTTDSGLFVF VVGGDAKYTI PIPTDIWFLG
FRAGKVHPEW LCKHAGQLLT CDKDTGLLSY KQVLINKDLI VNTNWSYMSF FDPTIGAPRH
ARQGWCWLKA LACTSMPFER LPVAALVSAG YLLNNGVDCP VVKRGKHYHV DRRGVKISLL
VENLVGAEIE EMDCDALTSS DARGNSLLAG ALEAVSRRPV FRETSNVMLN LDATLASILH
QTAQSKKRAH PILTQTLTEG ERDYFISEVG DLYLEFRNGY RGGHSLLNAF RQVFNFKLHA
DLRGFTINSI GGSLAYHMKS DVSFHHVCSP ILEGKDGARR WKDLNQMFLA TNVSGVLTGD
KMNVLCNTFC SSFCNRRLQD CRVPCTAMTA VDVYDIPLQD IVNAMSRKGT LIMKYALMFP
PELLNRDGTI VAFKTDVTVT KTGDEVTYYV GSCGEDYTHS WSVIKSLILT DSIISDQGLF
YSVEMVEQMG PYMCFEVALS SMKHHTTQPT RKFKAWYKDM CEIIVILKPP PHLRIERQFV
ERDFTNRFLL YLTNAAPSYD DRTFEYALSG LRAHRSTMIV GSKIIHSKID IPTDLSEPLA
ATFLREAVNR RHQNRKSLHP FSIWSRFIEF LKRMYNRVKG FLKLDFFFKD DPDVALYNKL
ISKDEPLIRD CPDFIVEEIQ SEVLRTETQI EIMEDIVETV RSLVLQQIDP PEEDNEEQVK
ERGGLAGGAK SSWFDFLLPK GPGLSEQEGD LDNFNLRLWR LLRKMTGWVN AGISWSSTEL
ENIPVVGPIL RMLFTFCMRF KTLLSTAFSY CCGSRFRKEE TQKKVTLLMQ LVTYSEKFVN
FLKGVSSCVS NKPNAPGKRG FLSELGEFGM GICGAILSKP KEFATDFFKE QSRNIKHELG
CFAVRLGVKK YEKWIKPTPK SILKKHLNKL LGIASSAAGY SPLLVVLLGG CYAVYNYRSE
IVEKASHMIT ALKQYRLNSI DDAFSVCLGI VGAWQKGLPY TPLLNLIWKN PMLEGIFLQH
CCDAVWTGNL SLRLLMEAYV TYPLRTTCSL ISKREDEPVV PTSPVRIEIG VNKPSINKTE
VVKQILAGLG TLGKGKPQPT DSQGEDKSAQ QHLSHTPSKG KGVVVAQPMP RELRAPPVEI
AGPSGSKQEI PEVVEAKAHS AAPLLPADIP TFDYVAKILN QEVGTNLHPT PVVEEIPSVS
ESPVLTQPSG VDTTVQIEPT TVVAPETVAQ PEHVPSAVEQ IYNSIMSSEE QSKREWNDDE
RNVAENIMVG ASDASSSSSG DEAVYAPIPL SHSLSAEVKN DLKINGLDFM LSANPLQKFV
ELTQFNRQVD PRTVNKAIIE WILLECREFF LQCSVKSSLI GAGFVTDSKG KRVHSSVNRE
IHSQHYLLKY YDAGKDFLAH HGYLQGTCVC YSLPRKEFLY CLERAAVEDY PLFVLNYKEP
PYAYLKVRGI TSSLPRIFDK GESLLKITLT NAVPGGGKTY TLVENFKAIE GKGWVLTANR
GSAEAIRGDI GPNNSWSKRV KTADSFIIGL SCTLHQPGQT VFVDECFLMH PGQLEACLRA
LQPSRVEIYG DRRQIPYINR VVGFNAQFTN LDVSNMEYKE LLRSFRCPAD VCHLLSTLKF
PDGAAYTGPV KSVGRHGILK SVSFARDTTP KVSDLMSCDC ILTFCQSEKH EMNELVRKSV
PPNIRERITV RTVHEAQGAT FKNILLVRTK WADDTVFSSL PHILVALSRH THSLKYYCPA
THRDKGVGKY VGLGEKLTEF VASQSLIEHT L
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