ID A0A3G8JI63_9ACTN Unreviewed; 675 AA.
AC A0A3G8JI63;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Multidrug resistance protein 3 {ECO:0000313|EMBL:AZG44703.1};
GN Name=bmr3_1 {ECO:0000313|EMBL:AZG44703.1};
GN ORFNames=D7316_01289 {ECO:0000313|EMBL:AZG44703.1};
OS Gordonia insulae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=2420509 {ECO:0000313|EMBL:AZG44703.1, ECO:0000313|Proteomes:UP000271469};
RN [1] {ECO:0000313|EMBL:AZG44703.1, ECO:0000313|Proteomes:UP000271469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS17-SY073 {ECO:0000313|EMBL:AZG44703.1,
RC ECO:0000313|Proteomes:UP000271469};
RA Kim Y.S., Kim S.B.;
RT "Gordonia insulae sp. nov., isolated from an island soil.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP033972; AZG44703.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3G8JI63; -.
DR KEGG; gom:D7316_01289; -.
DR OrthoDB; 7375466at2; -.
DR Proteomes; UP000271469; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17502; MFS_Azr1_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR23501:SF197; COMD; 1.
DR PANTHER; PTHR23501; MAJOR FACILITATOR SUPERFAMILY; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01036; TCRTETB.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271469};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 24..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..507
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 675 AA; 71522 MW; C285008021F203F9 CRC64;
MTEGQAPTAG PADAPADELD QRKIWSIFGG LMLAMLLAAL DQTIVSTALP TIVNDLGGAE
HLTWVVTAYM LATTATTPLW GKLGDLYGRR YLFIGCVVLF LIGSALCGTA MSMTQLIAYR
ALQGVGAGGL MVLAQAIIGD VVPPRERGRY QGMFGAVFGL ASVAGPLLGG FFVDNLSWRW
VFYINLPIGI VALIAVILVL PSTSAHVKAT IDYLGIFLLA LIATCIVLAT SFGSLWGWGS
PKILGLVAIA IIAIAAFVVV EKRAPEPVLP VRLLTNRVFA IASSIGFVVG FAMFGAITFL
PLFLQSVQGA SATSSGLRMI PMMAGLLITS IASGQLISRN GRYKIYPIVG CAVFTVALYL
LSTMDRTTSD VLTSVYLFVL GVGLGMVMQV LVLAVQNAVE YRDLGTGTSG ATFFRTIGAS
VGVAVFGAVF NSQLDAHLTG DVPRAAVGPC SAEVLEASTL SLPSCPPAVQ AWFLDGFTDA
FQVVFLVAVP IGFLAFALSW LLPEVELRTV TRTPDPGESF GMPSARTSLE ELRLQVWRTL
GREDRLRIWE IVVATAGSPL SRGEAWMVSR VAEETTRDLA TMSSVSGTPQ PVVEQTAAAL
AERGMVTIDG DEVSITPPGA AEADRLLAAQ RERLRAFVAD YPGSDEADVD EMLDEIARRL
HDEVPAQGLV SPGGR
//
