ID A0A3G8JNC7_9ACTN Unreviewed; 412 AA.
AC A0A3G8JNC7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN Name=thlA_1 {ECO:0000313|EMBL:AZG45680.1};
GN ORFNames=D7316_02280 {ECO:0000313|EMBL:AZG45680.1};
OS Gordonia insulae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=2420509 {ECO:0000313|EMBL:AZG45680.1, ECO:0000313|Proteomes:UP000271469};
RN [1] {ECO:0000313|EMBL:AZG45680.1, ECO:0000313|Proteomes:UP000271469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS17-SY073 {ECO:0000313|EMBL:AZG45680.1,
RC ECO:0000313|Proteomes:UP000271469};
RA Kim Y.S., Kim S.B.;
RT "Gordonia insulae sp. nov., isolated from an island soil.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP033972; AZG45680.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3G8JNC7; -.
DR KEGG; gom:D7316_02280; -.
DR Proteomes; UP000271469; Chromosome.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:AZG45680.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000271469};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:AZG45680.1}.
FT DOMAIN 9..272
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..409
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 93
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 367
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 397
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 412 AA; 43045 MW; BE27E9ACDEC296E4 CRC64;
MKDTVLRDVV ICEPVRTPIG RYGGMFKGVT AVDLGVTALR GLLDRTGLAP ELVDDVVLGH
CNGNSEAPAI GRVVALDAGL PITVGGMHID RRCGSGLQAV IQAAFQVAAG DNDVVIAGGT
ESMSNASFYS VDMRWGGART GIAMHDSLVR ARSTAGGKNY PVPGGMIETA ENLRKEYEIS
RAEQDELAVE SHLRAVRAQK DGILAEEIIP VTVRGRGGDQ IIDTDEHPRP DVSVQSLAKL
KPIMGTTDPD ATVTAGNASG QNDAAAMCIV TTPDVAQQHG LRPLVRLVSW AVAGVAPRTM
GIGPVPATEK ALAKAGLTLT DIDVIELNEA FAAQALAVTR EWGFGRFGAG GDFDRTNVHG
SGISLGHPVG ATGVRMLASL ARELRRRDAR YGLETMCIGG GQGLAAVFEN VG
//
