ID A0A3L6QSE7_PANMI Unreviewed; 827 AA.
AC A0A3L6QSE7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Phospholipase D {ECO:0000256|ARBA:ARBA00012027, ECO:0000256|PIRNR:PIRNR036470};
DE EC=3.1.4.4 {ECO:0000256|ARBA:ARBA00012027, ECO:0000256|PIRNR:PIRNR036470};
GN ORFNames=C2845_PM04G12860 {ECO:0000313|EMBL:RLM86264.1};
OS Panicum miliaceum (Proso millet) (Broomcorn millet).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Panicinae; Panicum.
OX NCBI_TaxID=4540 {ECO:0000313|EMBL:RLM86264.1, ECO:0000313|Proteomes:UP000275267};
RN [1] {ECO:0000313|Proteomes:UP000275267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30683860; DOI=10.1038/s41467-019-08409-5;
RA Zou C., Miki D., Li D., Tang Q., Xiao L., Rajput S., Deng P., Jia W.,
RA Huang R., Zhang M., Sun Y., Hu J., Fu X., Schnable P.S., Li F., Zhang H.,
RA Feng B., Zhu X., Liu R., Schnable J.C., Zhu J.-K., Zhang H.;
RT "The genome of broomcorn millet.";
RL Nat. Commun. 10:436-436(2019).
CC -!- FUNCTION: Hydrolyzes glycerol-phospholipids at the terminal
CC phosphodiesteric bond. {ECO:0000256|PIRNR:PIRNR036470}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000798,
CC ECO:0000256|PIRNR:PIRNR036470};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913,
CC ECO:0000256|PIRNR:PIRNR036470};
CC -!- SIMILARITY: Belongs to the phospholipase D family. C2-PLD subfamily.
CC {ECO:0000256|ARBA:ARBA00010683, ECO:0000256|PIRNR:PIRNR036470}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLM86264.1}.
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DR EMBL; PQIB02000011; RLM86264.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L6QSE7; -.
DR STRING; 4540.A0A3L6QSE7; -.
DR Proteomes; UP000275267; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR CDD; cd09139; PLDc_pPLD_like_1; 1.
DR CDD; cd09142; PLDc_pPLD_like_2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR024632; PLipase_D_C.
DR InterPro; IPR015679; PLipase_D_fam.
DR InterPro; IPR011402; PLipase_D_pln.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR18896:SF137; PHOSPHOLIPASE D ALPHA 4; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12357; PLD_C; 1.
DR Pfam; PF00614; PLDc; 1.
DR PIRSF; PIRSF036470; PLD_plant; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50035; PLD; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRNR:PIRNR036470};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036470};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR036470};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR036470};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000275267}.
FT DOMAIN 1..136
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 663..690
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 827 AA; 91225 MW; 57AF5DF6CC62CD2C CRC64;
MGSQQDEGGA AAEVVYLHGV LEVTVFEAEQ LHNAIHGRIM EATEKLQDTM GVHCLQHSRL
YVDVDVGAAR VARTREVEFH PTSPAWNQSF RLHCAYPAAA VTFTVKNQHL IGAGVLGAGS
VPAARVASGQ PVECWLALRG GEHDHETHTP SLRVRLQFLD VERDPSWGAG VRLPGFAGVK
PAFFPERTGC SVTLYQNAHL TDEFDPGVRL DGGRAYRPAR LWEDLYAAIR DARRFVYVAG
WSVSTEITLV RDPGRMVPGA EGVTLGELLK RKADEGVAVL VMPWQDNTSV SFLGNAGLMK
THDEETRRFF EGTNVRCFLC PRNADASLTM VQHVQTSAEF THHQKTATLD AATPGTGDDG
HHVVSFIGGI DLCDGRYDDE NHTLFRDLDT TYLHDFMQNN YKHACLRRGG PREPWHDVHC
RLEGPAAWDV LTNFEQRWRK QAPEGMRGCL LDLSPAALPD PAGLGDDTGS WNVQVFRSID
DASVVGFPSD PAEAAALGLT SGKDVTVDRS IQTGYVEAIR RARRFIYIEN QYFLGGCASW
AEDRGAGCLN LVPVEIALKL AAKIRHGERF AAYVVTPMWP EGLPAGEAVQ AILLWNRRTV
EMMYGIVMEA IDDAGLRGQA HPCDYLNFFC LGNREAPLPG EYSPPETPEK DTDYWRAQVN
RRGPIYVHAK LMIVDDEYVI VGSANLNERS LAGNRDSEIA QGSYQPAHLN GPCGRARGEV
HGFRMSLWHE HFMARHAGED GGGDDRAVFL EPESVECVRA VRRAADRLWG VYTQDRVENL
PGHLLPFPIT VSEFGEVADL PADGCFPDTR APVKGRKAAK LPDILTT
//
