ID A0A3L6RMB9_PANMI Unreviewed; 665 AA.
AC A0A3L6RMB9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Apyrase 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=C2845_PM13G18170 {ECO:0000313|EMBL:RLN05192.1};
OS Panicum miliaceum (Proso millet) (Broomcorn millet).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Panicinae; Panicum.
OX NCBI_TaxID=4540 {ECO:0000313|EMBL:RLN05192.1, ECO:0000313|Proteomes:UP000275267};
RN [1] {ECO:0000313|Proteomes:UP000275267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30683860; DOI=10.1038/s41467-019-08409-5;
RA Zou C., Miki D., Li D., Tang Q., Xiao L., Rajput S., Deng P., Jia W.,
RA Huang R., Zhang M., Sun Y., Hu J., Fu X., Schnable P.S., Li F., Zhang H.,
RA Feng B., Zhu X., Liu R., Schnable J.C., Zhu J.-K., Zhang H.;
RT "The genome of broomcorn millet.";
RL Nat. Commun. 10:436-436(2019).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLN05192.1}.
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DR EMBL; PQIB02000008; RLN05192.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L6RMB9; -.
DR STRING; 4540.A0A3L6RMB9; -.
DR Proteomes; UP000275267; Chromosome 13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF3; APYRASE 6-RELATED; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000275267};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 171..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 105..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..130
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 324
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 354..358
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 665 AA; 72435 MW; 7A2861D6CCD5E3A3 CRC64;
MLAHPACQRR WQFGCPAAHS AGLLPNAGIL LAHRPHCWPA AARARCPPLH LAAALRHYPA
SRRDAEGASQ HRYAMAMAAR PPHPGPHARS PHRILAATSP RRAGTLHIPA DAPRPPSAPN
EPPGPICSPR PMRRPNARGE PKGQTLAPAP SPAARIRMGA PRRQPSTRRR VACALALLAA
SAFALLLLLA SRSAPPRYGV IIDAGSTGSR VHVIAYRAGA GRGAPPQLDW ARTASLKVNP
GLSSFAADPR GAGLSLAPLV EFARRRVPRE RWEDTEVRLM ATAGLRLLDA AVAESVLESC
RDVLRQSGFL FQDKWATVIS GTEEGIYAWV AANYALGSLG GDPHDTTGII ELGGASVQVT
FVTGEPLPPE FSHVLKFGDV SYNLYSHSFL QLGLNVAYES LHDLLSSPGL KSMAAHLITQ
TKYKDPCTPR GFTSMAGTTK LPVSVLEPKV EYRPFAHALG NFSECRSAAL TLLQKGNEGC
AYHECRLGAA FVPELEGKFL ATENFYHTSK FFGLHSKSFL SDLMVAGEKF CHGDWSKIKK
KYSSFNEGEL LLFCFSSAYI IALLHDTLKM PLEHKRIDVV NQIHGVPVDW ALGSFIVQTT
LNRTEYSDSS VSYLNSYDSC GLAPIFLITT VVVFTAFSIL RWRGPQLKTI YDMEKGRYII
TRVSR
//
