ID A0A3L6RX28_PANMI Unreviewed; 906 AA.
AC A0A3L6RX28;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 28-JUN-2023, entry version 19.
DE SubName: Full=Histone-lysine N-methyltransferase EZ1 isoform X2 {ECO:0000313|EMBL:RLN11511.1};
GN ORFNames=C2845_PM09G03980 {ECO:0000313|EMBL:RLN11511.1};
OS Panicum miliaceum (Proso millet) (Broomcorn millet).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Panicinae; Panicum.
OX NCBI_TaxID=4540 {ECO:0000313|EMBL:RLN11511.1, ECO:0000313|Proteomes:UP000275267};
RN [1] {ECO:0000313|Proteomes:UP000275267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30683860; DOI=10.1038/s41467-019-08409-5;
RA Zou C., Miki D., Li D., Tang Q., Xiao L., Rajput S., Deng P., Jia W.,
RA Huang R., Zhang M., Sun Y., Hu J., Fu X., Schnable P.S., Li F., Zhang H.,
RA Feng B., Zhu X., Liu R., Schnable J.C., Zhu J.-K., Zhang H.;
RT "The genome of broomcorn millet.";
RL Nat. Commun. 10:436-436(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLN11511.1}.
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DR EMBL; PQIB02000006; RLN11511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L6RX28; -.
DR STRING; 4540.A0A3L6RX28; -.
DR Proteomes; UP000275267; Chromosome 9.
DR GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS51576; SAM_MT43_EZ; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:RLN11511.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000275267};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RLN11511.1}.
FT DOMAIN 640..739
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 754..869
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 100769 MW; 672473F8050A88C2 CRC64;
MEAAAAAAAS SASASASAGR SRPSTSAAQV TSITGVRAEE ENAASPYVLT VIDSLKKRIT
ADRLTYIKNR IGENKANLST FTQRTYNLSK NRQNNTSKGT DLAPNLLTKR QDDALCTLHS
VDICPADKDG SNFQDESPFS SSNVILGGNL NAKNAIRPIK LPEASKLPPY TTWIFLDRNQ
RMSEDQSVLG RRRIYYDASC GEALICSDSE DEAIEDEEEK KEFKHSEDCI IQMTVQECGM
SDAARYEILH GEKTQDSCKK VTEQNARVED LYGDKDLDAA LDSFDNLFCR RCLVFDCKLH
GCSQDLVFPT EKQQAWNGIA DSVPCGLHCH KQASEPDSVA AIDHMLIDGE EPTHPSGNAT
NQPGTDRKKN GSSGRKTKSQ QSETSSTARA VSESSDSEVH PISNKSPQPS PSPSKVKIGP
KGGIRKITNR RIAERILMSV KKGQREMASS DSNSVSESPL AARDTRILLR SDARNGNKES
IVSSQDTPNT RSIRKKITPQ FGNSSASAEA QNDSMEEDGY DSSRKEEFVD ENICKQEDNF
RSWKPIEQGL LVKGLEIFGR NSCLIARNLL GGMKTCRDVF QYMNYIENSS ASGTLSGVDS
LVKGYIKGNE LRSRSRFFRR RGKVRRLKYT WKSAGYHSIR KRITERKDQP CRQYNPCGCQ
SACGKQCPCL TNATCCEKYC GCSKICKNRF RGCHCAKSQC RSRQCPCFAA DRECDPDVCR
NCWVGCGDGT LGVPNQRGDN YECRNMKLLL KQQQRVLLGR SDVSGWGAFL KNSVSKHEYL
GEYTGELISH KEADKRGKIY DRENSSFLFN LNNEFVLDAY RMGDKLKFAN HSPDPNCYAK
VIMVAGDHRV GIFAKERILA GEELFYDYRY EPDRAPAWAR KPEDSRGKDD GPSNGRAKKL
AQNTRG
//
