ID A0A3L6THR5_PANMI Unreviewed; 541 AA.
AC A0A3L6THR5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN ORFNames=C2845_PM01G05120 {ECO:0000313|EMBL:RLN38668.1};
OS Panicum miliaceum (Proso millet) (Broomcorn millet).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Panicinae; Panicum.
OX NCBI_TaxID=4540 {ECO:0000313|EMBL:RLN38668.1, ECO:0000313|Proteomes:UP000275267};
RN [1] {ECO:0000313|Proteomes:UP000275267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30683860; DOI=10.1038/s41467-019-08409-5;
RA Zou C., Miki D., Li D., Tang Q., Xiao L., Rajput S., Deng P., Jia W.,
RA Huang R., Zhang M., Sun Y., Hu J., Fu X., Schnable P.S., Li F., Zhang H.,
RA Feng B., Zhu X., Liu R., Schnable J.C., Zhu J.-K., Zhang H.;
RT "The genome of broomcorn millet.";
RL Nat. Commun. 10:436-436(2019).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLN38668.1}.
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DR EMBL; PQIB02000001; RLN38668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L6THR5; -.
DR STRING; 4540.A0A3L6THR5; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000275267; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF2; 3-KETOACYL-COA SYNTHASE 10; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000275267};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..402
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 435..515
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
FT ACT_SITE 259
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 338
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 436
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 440
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 469
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 473
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
SQ SEQUENCE 541 AA; 60039 MW; FBAC47C6A92E3D6D CRC64;
MAREQALLST EIVNRGVEPS GPDAGSPTFS VRVRRRLPDF LQSVNLKYVR LGYHYLISHG
VYLATIPVIV LVCGAELGSL SRDELWAKVW GEASYDLATV LAFLAVLAFT ISVYIMSRPR
PVYLIDFACY KPADELKVSK AEFIDLARKS GKFDDESLAF QSRLLAKSGI GDESYMPRCV
FEPNANCATM KEGRAEASTA MFAALDELFD KCRVRPKDVG VLVVNCSLFN PTPSLSAMIV
NHYKMRGNIL SYNLGGMGCS AGLIAVDLAR DMLQASGAGL AVVVSTEAVS FTWYPGKRRS
MLIPNAFFRA GCAAVLLSNR RRDFHRAKYQ LEHVVRTHKG ADDRAFRSVY QEEDEQRIKG
LSISRDLLEV GGHALKTNIT TLGPLVLPFS EQLLFFAGVL FRHLFPSKAS STPPPGEEAS
AAAAPYIPDF KRAFEHFCMH AASRDVLEHL QANLGLRDAD LEASRAALHR FGNTSSSSIW
YELAYLEAKG RVRRGDRVWQ LAFGSGFKCN SAVWRAVRRV RRPARSPWLD CIDQYPARMD
A
//
