ID A0A3L6ZWH9_9MICO Unreviewed; 279 AA.
AC A0A3L6ZWH9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=Metallo-beta-lactamase type 2 {ECO:0000256|ARBA:ARBA00017223};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE AltName: Full=B2 metallo-beta-lactamase {ECO:0000256|ARBA:ARBA00030107};
DE AltName: Full=Metallo-beta-lactamase type II {ECO:0000256|ARBA:ARBA00033087};
GN ORFNames=D9V29_04270 {ECO:0000313|EMBL:RLP72376.1};
OS Mycetocola manganoxydans.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Mycetocola.
OX NCBI_TaxID=699879 {ECO:0000313|EMBL:RLP72376.1, ECO:0000313|Proteomes:UP000270299};
RN [1] {ECO:0000313|EMBL:RLP72376.1, ECO:0000313|Proteomes:UP000270299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB209002 {ECO:0000313|EMBL:RLP72376.1,
RC ECO:0000313|Proteomes:UP000270299};
RA Li J.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Class-B
CC beta-lactamase family. {ECO:0000256|ARBA:ARBA00005250}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLP72376.1}.
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DR EMBL; RCUV01000005; RLP72376.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L6ZWH9; -.
DR OrthoDB; 2273115at2; -.
DR Proteomes; UP000270299; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd16282; metallo-hydrolase-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR42951:SF20; BETA LACTAMASE; 1.
DR PANTHER; PTHR42951; METALLO-BETA-LACTAMASE DOMAIN-CONTAINING; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:RLP72376.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000270299};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 20..209
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 279 AA; 30352 MW; 117829152E91F674 CRC64;
MSSWNEVADR VYQRRYDPLD VSVCVVAGSD GLLLVDTRCN PREAGELAAD VAELSSAPIR
WVANTHAHYD HSFGNQVFPD TSIFGHHLIA RHFAEFEGPR LESWLAAPES QPHYDWRDVR
LTPPTVPVTD VLSLDLGDRL VRFHPLPPGH TDTDLIVEIP DAATWLLGDV VEESGPPMYG
SGSFPLGWPG VLDNIAELIA PGDVLVPGHG RPVDRAFLLE QAAVLHIVAD GIRSSFDQSE
PIESASERVA SMSRLPLEIV ESAVLRGYTQ LAASAGASE
//
