ID   A0A3L8P347_9ACTN        Unreviewed;       348 AA.
AC   A0A3L8P347;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:RLV49760.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:RLV49760.1};
GN   ORFNames=D9V37_07585 {ECO:0000313|EMBL:RLV49760.1};
OS   Nocardioides mangrovicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=2478913 {ECO:0000313|EMBL:RLV49760.1, ECO:0000313|Proteomes:UP000281708};
RN   [1] {ECO:0000313|EMBL:RLV49760.1, ECO:0000313|Proteomes:UP000281708}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4Q3S-7 {ECO:0000313|EMBL:RLV49760.1,
RC   ECO:0000313|Proteomes:UP000281708};
RA   Li F.;
RT   "Marmoricola sp. 4Q3S-7 whole genome shotgun sequence.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLV49760.1}.
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DR   EMBL; RDBE01000006; RLV49760.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3L8P347; -.
DR   OrthoDB; 105475at2; -.
DR   Proteomes; UP000281708; Unassembled WGS sequence.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:RLV49760.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000281708}.
FT   DOMAIN          16..343
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   348 AA;  37563 MW;  F7CD12BF78D41D43 CRC64;
     MAEPGAGLAE FIRALPKAEL HVHHVGSASP EVVAMLAERH ADSPVPTDPD ELRRYFAFRD
     FGHFITVYLS VVDLVRTPED VRLLTYEIAR EMAVGQRIRY AELTCTPYTI VLPHDDEHGM
     AIEAYVEAIE DARVAAEREL GIVLRWIYDI PGEAGLPAAE ATLDMALHHA PDTLVGFGLG
     GPEVGVPRPQ FKPYFDAARA AGLHSVPHAG ETTGPQTIWD ALNELGAERI GHGTSAAQDP
     ELLARLAETG VPLEVCPSSN LATKAVADLA EHPLPRFVEA GVRVSINTDD PPMFGTTLNH
     EYEVAAGLLG LDEAGLAELA RSAVRSSYAP DEVRARVLEE INSVTQRG
//