ID   A0A3L8P5R6_9ACTN        Unreviewed;       342 AA.
AC   A0A3L8P5R6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:RLV50585.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:RLV50585.1};
GN   ORFNames=D9V37_01025 {ECO:0000313|EMBL:RLV50585.1};
OS   Nocardioides mangrovicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=2478913 {ECO:0000313|EMBL:RLV50585.1, ECO:0000313|Proteomes:UP000281708};
RN   [1] {ECO:0000313|EMBL:RLV50585.1, ECO:0000313|Proteomes:UP000281708}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4Q3S-7 {ECO:0000313|EMBL:RLV50585.1,
RC   ECO:0000313|Proteomes:UP000281708};
RA   Li F.;
RT   "Marmoricola sp. 4Q3S-7 whole genome shotgun sequence.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLV50585.1}.
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DR   EMBL; RDBE01000001; RLV50585.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3L8P5R6; -.
DR   OrthoDB; 105475at2; -.
DR   Proteomes; UP000281708; Unassembled WGS sequence.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:RLV50585.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000281708}.
FT   DOMAIN          11..334
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   342 AA;  36829 MW;  FFB0884375D8212C CRC64;
     MSARRELRAL PKAHLHLHFT GSMRHATLLE LAERDGHVLP DALVEDWPPT LSAADEKGWF
     RFQRLYDVAR SVLRTEADVR RLVRETAEDD VADGGRWLEI QVDPSGYATL FGGVTAFTDL
     VLDAVADASR RTGLGIAVVI AANRTRHPLD ARTLARLATQ YVDRGVVGFG LSNDERRGRT
     AEFAPAFRIA ERAGLMLDPH GGELVGPSHV RACLDDLHAQ RLGHGVRSAE DPALLERIAS
     SGVALEVCPT SNVALGVYTD LASVPLPQLL EAGATVALGA DDPLLFGSRL NAQYATMRAA
     HALEDADLAE LARMSFRASR APSDLVATAL ADVDAWLAQS PS
//