ID A0A3L8PYB3_9GAMM Unreviewed; 386 AA.
AC A0A3L8PYB3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Heme biosynthesis protein HemY {ECO:0000313|EMBL:RLV60290.1};
GN ORFNames=D5018_07805 {ECO:0000313|EMBL:RLV60290.1};
OS Parashewanella curva.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Parashewanella.
OX NCBI_TaxID=2338552 {ECO:0000313|EMBL:RLV60290.1, ECO:0000313|Proteomes:UP000281474};
RN [1] {ECO:0000313|EMBL:RLV60290.1, ECO:0000313|Proteomes:UP000281474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C51 {ECO:0000313|EMBL:RLV60290.1,
RC ECO:0000313|Proteomes:UP000281474};
RA Wang G.;
RT "Phylogeny of the Shewanellaceae, and recommendation for two new genera,
RT Pseudoshewanella and Parashewanella.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLV60290.1}.
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DR EMBL; QZEI01000018; RLV60290.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L8PYB3; -.
DR OrthoDB; 7067577at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000281474; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000281474};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..132
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
SQ SEQUENCE 386 AA; 43911 MW; 978ACE70E8B781C8 CRC64;
MIRTLAYIVI ILLGLVLSPW ILSHTGYLYL SIGDYEVETS VVFAVVALLV IFSAIQLIEW
LFVGLINIFV RRGWLSSRWR RQSARKHTLQ GALAIAEEDW VNAEKSMCKG ASNGELPLVN
WLAAARAAHH QGSTEQRDHY LNQAEKLADN KLSIATTRVR YLIQQGELET ARVQLDKLIA
ANSNKPALIK LGLELYHLQQ DWSAIKLLLP KVTKLKLLNQ SELEELQQQV NRALLKQVEH
KPELEKVWHW LSRKERKTSA NLAEYAISLA RLGDTIEAKK IIYKAIKSHP VNEFFDLLPS
IVNAGDDDIR KLLAGLESSQ DNNASYHRCL AKLNQQTNNF SEAKHHWQRV IELQPSVSSW
TALGKLHEQL GEQAKALNCY RHALQF
//
