ID A0A3L9M7N6_9FLAO Unreviewed; 411 AA.
AC A0A3L9M7N6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945,
GN ECO:0000313|EMBL:RLZ09247.1};
GN ORFNames=EAH69_08480 {ECO:0000313|EMBL:RLZ09247.1};
OS Flavobacteriaceae bacterium YIM 102668.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=2479857 {ECO:0000313|EMBL:RLZ09247.1, ECO:0000313|Proteomes:UP000275348};
RN [1] {ECO:0000313|EMBL:RLZ09247.1, ECO:0000313|Proteomes:UP000275348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 102668 {ECO:0000313|EMBL:RLZ09247.1,
RC ECO:0000313|Proteomes:UP000275348};
RA Chen X.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLZ09247.1}.
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DR EMBL; RDOJ01000010; RLZ09247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L9M7N6; -.
DR OrthoDB; 9807233at2; -.
DR Proteomes; UP000275348; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR CDD; cd02134; KH-II_NusA_rpt1; 1.
DR CDD; cd22529; KH-II_NusA_rpt2; 1.
DR CDD; cd04455; S1_NusA; 1.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR025249; KH_dom_NusA-like.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR030842; NusA_bac.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR NCBIfam; TIGR01953; NusA; 1.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF13184; KH_5; 1.
DR Pfam; PF08529; NusA_N; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW ECO:0000256|HAMAP-Rule:MF_00945}.
FT DOMAIN 6..124
FT /note="Transcription factor NusA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08529"
FT DOMAIN 233..301
FT /note="KH"
FT /evidence="ECO:0000259|Pfam:PF13184"
SQ SEQUENCE 411 AA; 46768 MW; CE300C61F2B4F6D0 CRC64;
MDNLALIESF VDFKDEKSID RITLMKILEE TLQSVLRKKY GSDDNFDIIV NPDKGDLEIW
HNRIVVADGF SEDDALEIEL AEARLIEPDF EIGEEVSERI PIESLGRRAI LTLRQTLVAK
VMEHDNSNLY EKFKGIIGEI VTGEIHHIRH KHVIIMDEEQ NEMILPKENQ IPSDFFRKGE
TLRAIVDDVK LRGSKPQIIL SRTSPKFLEK LFEQEIPEIY DGLITIKNVV RIPGDKAKVA
VESYDDRIDP VGACVGMKGS RIHSIVRELR NENIDVINYT NNMSLFITRA LNPAKISNIE
INEEENKALV HVAADEVSKA IGKGGYNVRL ASKLVGMEID IFREGAQDED VELTEFVDEI
DDWVIEAFKA IGLDTAKSIL EQDVDDLVKR TDLEEETIQD VINILKSEFE D
//
