ID   A0A3L9Y6M7_9RHOB        Unreviewed;       733 AA.
AC   A0A3L9Y6M7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:RMA41766.1};
GN   ORFNames=D9R08_12960 {ECO:0000313|EMBL:RMA41766.1};
OS   Rhodophyticola porphyridii.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Rhodophyticola.
OX   NCBI_TaxID=1852017 {ECO:0000313|EMBL:RMA41766.1, ECO:0000313|Proteomes:UP000281343};
RN   [1] {ECO:0000313|EMBL:RMA41766.1, ECO:0000313|Proteomes:UP000281343}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MA-7-27 {ECO:0000313|EMBL:RMA41766.1,
RC   ECO:0000313|Proteomes:UP000281343};
RA   Jung H.S., Jeon C.O.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMA41766.1}.
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DR   EMBL; RCNT01000006; RMA41766.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3L9Y6M7; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000281343; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000281343}.
FT   DOMAIN          329..507
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          511..605
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   733 AA;  78862 MW;  91B040F4C723284C CRC64;
     MTDFTMKTDA DGVAVITWDV AGKSMNVLSR DAFEMVETLI DQALADDAVK GVVITSGKET
     FAGGMDLNVL ASIRQESGDD PAKGLFDFTM NGHRILRKLE RAGMDPKTNK GGKPVACAIT
     GTCMGIGTEI ALACHRRFMA DNPKAKIGLP EILVGIFPGG GGTTRYSRMV GAMAAAPVLL
     EGRTLDPAKA RSAQLVDEVV PAGELLEKAK EWVLSATDAD IVKPWDQKGW KMPGGAPYHP
     AGFMTFVGAS AMINGKTKGV YPAAKALLSA VYEGALVPFD TALTIEARWF TSVLMNPSSS
     AMIRSLFINK EALEKGANRP SVDDQKVRKV GILGAGMMGA GIAYVSANAG IEVVLIDNAQ
     EAADRGKSYS ADLLDKGMAR KKVTQEKKDQ VLGRITATTD YAALDGCDLI VEAVFEDVSV
     KAEVTKKTEA VIPEDAIFAT NTSTLPITEL AKASARPEQF IGIHFFSPVD KMMLVEIIRG
     EKTGDVAVAK ALDFVRQIRK TPIVVNDARF FYANRCIIPY INEGIRMVKE GVAPALIENA
     AKLVGMPLGP LQLTDETSID LGVKIAKATK AAMGDAYDDS VDELLFWMEA EGRLGRKANA
     GFYTYDEKGK RLGLWDGLAD KYPLAEDQPD LIEVQHRLLF AQVLEAVRAL EDEVLMDIRE
     GDVGAILGWG FAPWSGGPFS WLDILGAPYA ADRCDQLTKA YGARFTTPDL LREMADKGQS
     FYGRFGPEAK AAA
//