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Database: UniProt
Entry: A0A3L9ZL87_9FLAO
LinkDB: A0A3L9ZL87_9FLAO
Original site: A0A3L9ZL87_9FLAO 
ID   A0A3L9ZL87_9FLAO        Unreviewed;       212 AA.
AC   A0A3L9ZL87;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Alkyl hydroperoxide reductase C {ECO:0000256|ARBA:ARBA00017462};
DE            EC=1.11.1.26 {ECO:0000256|ARBA:ARBA00013021};
DE   AltName: Full=Peroxiredoxin {ECO:0000256|ARBA:ARBA00032077};
DE   AltName: Full=Thioredoxin peroxidase {ECO:0000256|ARBA:ARBA00032824};
GN   ORFNames=BC961_2606 {ECO:0000313|EMBL:RMA73010.1};
OS   Flavobacterium weaverense.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=271156 {ECO:0000313|EMBL:RMA73010.1, ECO:0000313|Proteomes:UP000280368};
RN   [1] {ECO:0000313|EMBL:RMA73010.1, ECO:0000313|Proteomes:UP000280368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19727 {ECO:0000313|EMBL:RMA73010.1,
RC   ECO:0000313|Proteomes:UP000280368};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC       hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC       respectively. Plays a role in cell protection against oxidative stress
CC       by detoxifying peroxides. {ECO:0000256|ARBA:ARBA00037420}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+);
CC         Xref=Rhea:RHEA:62628, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.11.1.26;
CC         Evidence={ECO:0000256|ARBA:ARBA00000318};
CC   -!- SIMILARITY: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009796}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMA73010.1}.
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DR   EMBL; REFH01000011; RMA73010.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3L9ZL87; -.
DR   OrthoDB; 9812811at2; -.
DR   Proteomes; UP000280368; Unassembled WGS sequence.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:InterPro.
DR   CDD; cd03015; PRX_Typ2cys; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR000866; AhpC/TSA.
DR   InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR   InterPro; IPR019479; Peroxiredoxin_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR10681; THIOREDOXIN PEROXIDASE; 1.
DR   PANTHER; PTHR10681:SF128; THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL; 1.
DR   Pfam; PF10417; 1-cysPrx_C; 1.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   PIRSF; PIRSF000239; AHPC; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000280368}.
FT   DOMAIN          2..179
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   ACT_SITE        51
FT                   /note="Cysteine sulfenic acid (-SOH) intermediate; for
FT                   peroxidase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
SQ   SEQUENCE   212 AA;  23731 MW;  BE5E7B80F507F142 CRC64;
     MSLVGKKFPS IAVDAISEMG DNMKINIFEE ATKNNKKVLL FWYPKDFTFV CPTELHAFQA
     ALPEFEKRNT IVIGASCDTN EVHFAWLNTA KNNGGIEGVT YPILADTNRN LSNILGILDI
     DSTEYSEETD SVIIEGSNVT FRATYLIDET GKIFHESVND MPLGRNVNEY LRMVDAYTHI
     QEKGEVCPAN WEAGKEAMSA DRKSTAEYLS LN
//
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