ID   A0A3L9ZPX9_9FLAO        Unreviewed;       306 AA.
AC   A0A3L9ZPX9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Lactate dehydrogenase-like 2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:RMA72525.1};
GN   ORFNames=BC961_2928 {ECO:0000313|EMBL:RMA72525.1};
OS   Flavobacterium weaverense.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=271156 {ECO:0000313|EMBL:RMA72525.1, ECO:0000313|Proteomes:UP000280368};
RN   [1] {ECO:0000313|EMBL:RMA72525.1, ECO:0000313|Proteomes:UP000280368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19727 {ECO:0000313|EMBL:RMA72525.1,
RC   ECO:0000313|Proteomes:UP000280368};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMA72525.1}.
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DR   EMBL; REFH01000013; RMA72525.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3L9ZPX9; -.
DR   Proteomes; UP000280368; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT   DOMAIN          21..304
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          141..251
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   306 AA;  33564 MW;  3FA56AE3B0C8FD43 CRC64;
     MIMMFKKLVG IEPLELIPSA NKELESFAEI VILHENQPAD SAEIVARIGD ADAVLLSFRS
     TLGKEILEQC PNLKYIGMCC SLYTPESANV DINYANSRGI TVKGVLDYGD EGVVEYVVSE
     LVRCLHGFGT TSDGKPRKAW SIVPREITGL KVGIVGLGKS GGMVADALRF FGAEISYFAR
     SEKEDAKTKG YSFLPLQQLL AENEVIICCL NKNTVLLHEA EFKALGNSKI LFNTGLSPAW
     DLTAFESWIQ DDNLVYTDTL GALGIESLLK YTNVNCMQIS SGRTQQAFVR LSEKVLANLT
     AFSKKQ
//