ID   A0A3M0AC57_9GAMM        Unreviewed;       707 AA.
AC   A0A3M0AC57;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   ORFNames=DFR27_1381 {ECO:0000313|EMBL:RMA80025.1};
OS   Umboniibacter marinipuniceus.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Umboniibacter.
OX   NCBI_TaxID=569599 {ECO:0000313|EMBL:RMA80025.1, ECO:0000313|Proteomes:UP000267187};
RN   [1] {ECO:0000313|EMBL:RMA80025.1, ECO:0000313|Proteomes:UP000267187}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25080 {ECO:0000313|EMBL:RMA80025.1,
RC   ECO:0000313|Proteomes:UP000267187};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMA80025.1}.
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DR   EMBL; REFJ01000003; RMA80025.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0AC57; -.
DR   OrthoDB; 9801421at2; -.
DR   Proteomes; UP000267187; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267187};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..707
FT                   /note="prolyl oligopeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018195107"
FT   DOMAIN          28..427
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          485..700
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   707 AA;  77819 MW;  853C2826D90F7635 CRC64;
     MKKTAIGLAL LAFVGCTSNS NNSTIEYPVT AKGDVVDTYF GHQIADPYRW LEDDMSEETA
     DWVQAENEVT FSYLNQIPFR QELKDRLTEL WNYEKVGAPF TEGDYTYWYQ NDGLQNQYVL
     WRQKGESEAE IFLDPNQFSE DGTTSLAQVS FSDDGSLVAY SISEGGSDWR KIIVIDAETK
     QPIEDTLVDV KFSGISWLGN EGFYYSSYDK PDGSELSAKT DQHKLYYHQL GTSQSNDPVI
     FGGSEAEKHR YVGGGVSDDN RFLFISASVS TSGNKLFMLD LSDPEAELVT ILDDTRSDTY
     VIDNDGAKLY LVTNLDAPNK RIVTVDASNP TPENWVDFIA ETDNVLSPST GSGYFFAEYM
     VDAISQVKQY DYAGNFIRDI ELPGLGSVGG FSAKDDATTI YYSFTNYNTP GTTYSFEPHQ
     GVSDVYRASG IEFDASDYVS EQVFYTSKDG TEVPMIITHK RGIELDGTNP TILYGYGGFN
     ISLTPSFSVA NAVWLEQGGV YAVANLRGGG EYGKEWHDAG TQLQKQNVFD DFIAAAEYLN
     TAGYANSDHL AIRGGSNGGL LVGAVMTQRP DLMKVALPAV GVLDMLRYHT FTAGAGWAYD
     YGTAEQSEEM FKYLLGYSPV HNVKEGIPYP ATLITTGDHD DRVVPAHSFK FAAELQAKQG
     GTNPVLIRIE TNAGHGAGTP VSKTIEQYAD IFGFTLFNMG VTELSAD
//