ID   A0A3M0BMJ8_9AQUI        Unreviewed;      1044 AA.
AC   A0A3M0BMJ8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Cu(I)/Ag(I) efflux system membrane protein CusA/SilA {ECO:0000313|EMBL:RMA97756.1};
GN   ORFNames=CLV39_0382 {ECO:0000313|EMBL:RMA97756.1};
OS   Hydrogenothermus marinus.
OC   Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC   Hydrogenothermus.
OX   NCBI_TaxID=133270 {ECO:0000313|EMBL:RMA97756.1, ECO:0000313|Proteomes:UP000280842};
RN   [1] {ECO:0000313|EMBL:RMA97756.1, ECO:0000313|Proteomes:UP000280842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VM1 {ECO:0000313|EMBL:RMA97756.1,
RC   ECO:0000313|Proteomes:UP000280842};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMA97756.1}.
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DR   EMBL; REFO01000010; RMA97756.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0BMJ8; -.
DR   OrthoDB; 8270at2; -.
DR   Proteomes; UP000280842; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000280842};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        339..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        531..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        870..887
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        894..914
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        920..944
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        978..995
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1007..1032
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1044 AA;  117758 MW;  7EB837647441501F CRC64;
     MIEKIIYWSV KNKFIVLSVL VMIFGASIWA LKETPLDAIP DLSPPQVIVF TKWSGQSPSV
     VEDQITYPIV STLLSVPKVE TVRGISSFET SAVYVIFKEG TDIYWARSRV LEYLSQIKDK
     LPKTAQVTLG PDATGVGWVY EYALYSDKRN LWQLRTLQDW YLRYAILGVD GVSEVASIGG
     FVKGYQITIH PQKLRIYNIT IKDILKALRE NNNDTGGRII EKNGFEFIIQ GLGYIKKLDD
     IKNITIKIDK NAIPIRIKDI ADVELVPMGR RGLADLNGLG EVVGGIVIMR FGENAYKVIQ
     RVKEKIEEIK KSLPMDIKVI TTYDRSQLIE KAIATLKRAL FEESLIVILV VGIFLFHFRS
     SLVIILTLPL GILISFLFMK MLGITSNIMS LGGIAIAIGA MVDGAIVMVE NAHKHIEKIK
     EEKGKITEKD RVEAIILAAQ QVGKPIFFAL LIIVVSFLPI FALTGQEGLL FKPLAYTKTF
     AMLAASFLAI TVVPILMVWF IRGHIIPEHK NPINWLLLKI YTPIIKIVLK LRYLIVVFTI
     IAIGYIYPLY KKLSWEFMPT INEQTFMYMP VTPFGISADE AKNLTQLTDK IIASFPEVDT
     VFGKAGRADT ATDPAPLSMI ETIITFKPKE YWREGETYQS LMQEMEEKLK VPGLTNSWTY
     PIKGRIDMLL TGIRTPIGIK LYGDDLNKLQ NIATKIEKEL QKMPESLSVF ADRVAQGYYL
     NIDIKKEKLA RYGLTTDDIE TVIQTAIGGM PISTLYKGLE RYPMLIRFPY DYRTNIEAIK
     NLVIPTKYNR GVLVKDVADV YYTEAPSVIK SEKGMKVVYV YITPQPNITT EDYVKKANKI
     LKNINLPSGY FIEWAGQSKY LEHAKERLKF IVPLAILIIF LLVYMTFKDI KNTLIVMLSL
     PFSMIGGLWF LDYLHFNLSI AVVVGFLALL GVAAETAIVM VVYVEESVKK YIKENKKLNN
     KLFNEAIYEG AVLRVRPVIM TVSTIIAGLL PLLYISGVGS EVMQRIAAPM IGGIISATVL
     TLLIIPSIYA IIKKWQLRKE GLFE
//