ID A0A3M0GXM6_9ACTN Unreviewed; 311 AA.
AC A0A3M0GXM6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:RMB62126.1};
GN ORFNames=EAX62_06015 {ECO:0000313|EMBL:RMB62126.1};
OS Tessaracoccus antarcticus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Tessaracoccus.
OX NCBI_TaxID=2479848 {ECO:0000313|EMBL:RMB62126.1, ECO:0000313|Proteomes:UP000275256};
RN [1] {ECO:0000313|EMBL:RMB62126.1, ECO:0000313|Proteomes:UP000275256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDX10 {ECO:0000313|EMBL:RMB62126.1,
RC ECO:0000313|Proteomes:UP000275256};
RA Zhou L.Y., Du Z.J.;
RT "Tessaracoccus antarcticuss sp. nov., isolated from sediment.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB62126.1}.
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DR EMBL; REFW01000001; RMB62126.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0GXM6; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000275256; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000275256}.
FT DOMAIN 21..178
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 184..299
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 190
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 311 AA; 31676 MW; 9245C3548C337694 CRC64;
MTTSQHAGVP AAPGDPRPAG IGVIGLGVMG APMAGHILRA GFPVHVSARR HASAEQLIAA
GALWEPSPRS LAATCGVVVL MVPDLPDVEA VLDGPDGLLA GATAPMLVII SSTVSPEHLR
RLDARVRFAT DDRVHLVDAP VSGGQEGAEA GTLAVMLGGP EADAALARPV LEATGTVAHL
GPLGAGQVAK ACNQMIVAAT VMALGEAAVV AERAGLDVAA MFDLLGQGYA GSQILEVKKA
RFAQHDHSPS GAARFMVKDL GFARQEAALS RTVTPQLDVL QTCFTDLTAQ GFGDQDTSVV
QAWIESLGST G
//
