ID   A0A3M0I2L6_9ACTN        Unreviewed;       346 AA.
AC   A0A3M0I2L6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:RMB80319.1};
GN   ORFNames=CTZ28_40870 {ECO:0000313|EMBL:RMB80319.1};
OS   Streptomyces shenzhenensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=943815 {ECO:0000313|EMBL:RMB80319.1, ECO:0000313|Proteomes:UP000270471};
RN   [1] {ECO:0000313|EMBL:RMB80319.1, ECO:0000313|Proteomes:UP000270471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=193 {ECO:0000313|EMBL:RMB80319.1,
RC   ECO:0000313|Proteomes:UP000270471};
RA   Siqueira K.A., Liotti R.G., Mendes T.A.O., Soares M.A.;
RT   "Draft genome of actinobacteria isolated from guarana (Paullinia cupana
RT   (Mart.) Ducke.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMB80319.1}.
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DR   EMBL; PENI01000044; RMB80319.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0I2L6; -.
DR   OrthoDB; 105475at2; -.
DR   Proteomes; UP000270471; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000270471}.
FT   DOMAIN          11..340
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   346 AA;  38052 MW;  D96F7E80927CF2A2 CRC64;
     MERVRDVSDL PKAHLHLHFT GSMRPSTLLE LADKHGVRLP EALTDALTSG EPPRLRATDE
     RGWFRFQRLY DAARSCLRDP EDIQRLVREA AEEDLKDGSG WLEIQVDPTS YAPRLGGLIP
     ALEIILDAVH TASRDTGLGM RVLVAANRMR HPLDARTLAR LAVRFADRGV VGFGLSNDER
     RGMARDFDRA FHIAREGGLL SAPHGGELTG PSSVRDCLDD LNATRVGHGV RAAEDPRLLK
     RLADREVTCE VCPASNVALG VYEKPEDVPL RTLFEAGVPM ALGADDPLLF GSRLAAQYRL
     AREHHAFTDA ELAELARQSV RASAAPPNVR TKLLAGIDDW LTHPTT
//