ID A0A3M0ICW1_9ACTN Unreviewed; 825 AA.
AC A0A3M0ICW1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Clp protease {ECO:0000313|EMBL:RMB85890.1};
GN ORFNames=CTZ28_10235 {ECO:0000313|EMBL:RMB85890.1};
OS Streptomyces shenzhenensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=943815 {ECO:0000313|EMBL:RMB85890.1, ECO:0000313|Proteomes:UP000270471};
RN [1] {ECO:0000313|EMBL:RMB85890.1, ECO:0000313|Proteomes:UP000270471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=193 {ECO:0000313|EMBL:RMB85890.1,
RC ECO:0000313|Proteomes:UP000270471};
RA Siqueira K.A., Liotti R.G., Mendes T.A.O., Soares M.A.;
RT "Draft genome of actinobacteria isolated from guarana (Paullinia cupana
RT (Mart.) Ducke.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB85890.1}.
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DR EMBL; PENI01000005; RMB85890.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0ICW1; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000270471; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:RMB85890.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:RMB85890.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000270471};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 41..180
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 443..478
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 94..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 439..485
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 90333 MW; 1B593F247EEF3BDE CRC64;
MTTPGFGFGR SPFEEFDELM SRFFGGTGQA APARRIQRVD IGSLLSERGR ELVAEARDIA
AAEGSEDLDA RQLLAAATEH DSTRRLISEA GADPDGIRER LGTAAGSGAK TEPATLTPAA
KRALLDAYQL SRAEGASYIG PEHLLRALAA NPESAAGRVL AESGWEPTRM PTETAAERRR
PSSTPTLDEY GRDLTEDARA GRLDPVIGRD DEVEQTIEVL SRRSKNNPVL IGDPGVGKTA
IVEGIAQRIT AGDVPQTLKD KRLVSLDLAG LVAGTKYRGE FEERLKKLLD EVGEHGDELV
LFLDELHTVV GAGGGGEGAL DAGNMLKPAL ARGELHLIGA TTVDEYRKHI EKDAALERRF
APILVGEPTV DDTIAILHGL RDRYEAHHQV RITDEAVVAA AELSDRYITS RFLPDKAIDL
MDQAAARVRL RAKTPLADTR DVEDRIAALN REKDQAVADE EYERAKELRD RIKEAETRLA
EAAKEEKRTP EVTAEDIAEV VSRTTGIPVA QLTEEERERL MKLEEHLHER VVGQDEAITA
VARAVRRARA GMSDPNRPVG SFLFLGPTGV GKTELARALA AALFGDDSRM IRLDMSEFQE
RHTVSRLVGA PPGYIGHEEA GQLTEAVRRQ PYAVLLLDEV EKAHPDVFNT LLQLLDDGRL
TDSQGRTVDF KNTVVIMTSN IGADRILAAG VEDYTKVRES VMPVLHQRFR PEFLNRIDEI
IVFRGLDRAQ LRQIVDLLLE HTRRRLHAQE VGLEVTDEAA ALLANIGYQP DFGARPLRRT
IQREVDDRLA DLLLSGRLSA GDRAVVDAAE GSVTIRADKP AGVAD
//
