ID A0A3M0IED4_9ACTN Unreviewed; 406 AA.
AC A0A3M0IED4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Acetyl-CoA C-acyltransferase {ECO:0000313|EMBL:RMB84629.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:RMB84629.1};
GN ORFNames=CTZ28_18095 {ECO:0000313|EMBL:RMB84629.1};
OS Streptomyces shenzhenensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=943815 {ECO:0000313|EMBL:RMB84629.1, ECO:0000313|Proteomes:UP000270471};
RN [1] {ECO:0000313|EMBL:RMB84629.1, ECO:0000313|Proteomes:UP000270471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=193 {ECO:0000313|EMBL:RMB84629.1,
RC ECO:0000313|Proteomes:UP000270471};
RA Siqueira K.A., Liotti R.G., Mendes T.A.O., Soares M.A.;
RT "Draft genome of actinobacteria isolated from guarana (Paullinia cupana
RT (Mart.) Ducke.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB84629.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PENI01000010; RMB84629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0IED4; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000270471; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:RMB84629.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000270471};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:RMB84629.1}.
FT DOMAIN 5..274
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 391
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 42978 MW; 602DBF75A667F9F6 CRC64;
MPEAVIVSTA RSPIGRAFKG SLKELRPDDL TATIIQAALA KVPELDPKDI DDLMLGCGLP
GGEQGNNLGR IVAVLMGLDH LPGCTVTRYC SSSLQTSRMA LHAIRAGEGD VFISAGVEMV
SRFAKGNSDS WPDTHNPVFA EAEARTAAVA GQEGTAWHDP REDGLVPDAY IAMGQTAENL
ARWKGVTRRD MDEFGVRSQN LAEEAIKNGF WEREITPVTL PDGTVIGKDD GPRAGVTMEG
VQGLKPVFRP DGLVTAGNCC PLNDGAAAVV IMSDTKAREL GLTPLARIVS TGVSGLSPEI
MGLGPVEASR QALRRAGLTI DDIDLVEINE AFAAQVIPSY RELGIDLDRL NVNGGAIAVG
HPFGMTGARI TGTLINSLQW HDKQFGLETM CVGGGQGMAM VIERLS
//
