ID A0A3M0IF44_9ACTN Unreviewed; 1087 AA.
AC A0A3M0IF44;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:RMB80466.1};
GN ORFNames=CTZ28_40150 {ECO:0000313|EMBL:RMB80466.1};
OS Streptomyces shenzhenensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=943815 {ECO:0000313|EMBL:RMB80466.1, ECO:0000313|Proteomes:UP000270471};
RN [1] {ECO:0000313|EMBL:RMB80466.1, ECO:0000313|Proteomes:UP000270471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=193 {ECO:0000313|EMBL:RMB80466.1,
RC ECO:0000313|Proteomes:UP000270471};
RA Siqueira K.A., Liotti R.G., Mendes T.A.O., Soares M.A.;
RT "Draft genome of actinobacteria isolated from guarana (Paullinia cupana
RT (Mart.) Ducke.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB80466.1}.
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DR EMBL; PENI01000042; RMB80466.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0IF44; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000270471; Unassembled WGS sequence.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000270471}.
FT DOMAIN 753..833
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1087 AA; 116314 MW; DBF0B5675847153A CRC64;
MGAHMGTDRE YWSRVLSAGG CTAVPRWVGE PVAGVAAYET AAPDDLTAQL RAMARALKVP
LSAVLLAAHA KVLAALSAEH EVVTGYAAGP RRAPLPCRLT VEPATWRALV AAAQRAESDL
LAHREFPVDE LWRELRVAGP SYEVVFDPDG TEGGLVDDAV LGVGWAERGG RLALRLRYRT
QVLDAGYVAR VGGYHLAALR LMAADVDAEH ARQSLVSADE VHEQLEGLAG PGRVLPQARA
HELFEQRARA HPDRVAAVCG DRTWTYGELN ARANQLARAL LAHGLAREGV VAVVTERTLD
WLASVLAVFK AGGVYLPIEP HFPAGRILAT LSRAGCRLVL TESGGTGTLD EALTTLPDVE
KLLIEGAYRE GHDDGDVGVR VAPGQLAYIY FTSGSTGEPK GAMCEHAGML NHLYAKIDDL
GITEGRVVAQ TAPQCFDISL WQLVSALLVG GRTLLVGQDD VMDVERFLDT LVAGRVGVAQ
VVPSYLEVVV SCLEQHPREL PDLRCVSVTG EALKRELVQR WFAAQPRVKL INAYGLTETS
DDTNHEVMDK VPERVLLGHA INNVRVYVVD EQLSLVPLGA PGLIAFSGVC VGRGYVNDPE
RTAEAYREDP YRPGERLYLA GDWGRWHPGG KLEFLGRRDS QVKIRGFRIE IGEIENTLLR
VAGVRDAAVV VAERAGRSKH LIAFHTGRRL PTDELREALA AVLPGYMVPS AFHWQDALPL
TANGKTDKKA LTALAERTAP PAEDDTAAER DRAPLSPAER KLAAVWAELL GVPEPQIGRR
DHFFDRGATS LTAVKLTIAL DRAVSLKDIT RHPVLADLAA LLDGAARQPA ELLQPLAEPD
GTAACALVCF PHAGGNAVNY QPLASALAGS GTAVYAVELP GHDPAVHDEP FAPLARVAER
VAAEITARGL TRVMLWGHSA GAATALATAG VLQGRGVDVV RVFLAAQLPG TPAERRAAAG
ELTQRSDAEI AARLAEDSGY PELAELNARH AERVGAAYRH DCVSAHHYLA DALEAPPGVK
LAAPVTVVMA ADDPNTAGEP DRHRAWQALA ERVELHELPD GGHHFLRTRP AEAARAVLGA
TAPLASS
//
