ID A0A3M0IHQ5_HIRRU Unreviewed; 1321 AA.
AC A0A3M0IHQ5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=DUI87_35015 {ECO:0000313|EMBL:RMB88627.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB88627.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB88627.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB88627.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB88627.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|RuleBase:RU004020}.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB88627.1}.
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DR EMBL; QRBI01000317; RMB88627.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0IHQ5; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 2.30.30.850; -; 1.
DR Gene3D; 3.10.20.370; -; 2.
DR Gene3D; 3.30.70.270; -; 3.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF37; RIBONUCLEASE H; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 2.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50878; RT_POL; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221}.
FT DOMAIN 104..293
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 963..1152
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 720..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 148974 MW; FB63CB128EAAF1E1 CRC64;
MGIGNLLLVP EADYNLLGRD LIIEMGINIE VVNEEIKIKL CPLRVEDEEK INSEVWYTPD
SVGRLNIPPF SVIIKDPETP IRVKQYPISP EGKNGLKPEI ERLLSKGLLE SCMSPFNTPI
LPIKKADGSY RLVHDLREIN KRTVARFPVV ANPYTLLSRL GPEKQYYSVI DLKDAFWACP
LDEKSKDYFA FEWEDPVTHR RQQLRWTVLP QGFTESPNLF GQALEQILQE YQTGEGVTLI
QYVDDLLIAG ETEDKVRAES IRLLNFLSAK GLKVSKAKLQ FVEEEVKYLG HYLRKGEKKI
DPERVKGILS IPPPKSKEQI RQLLGLMGYC RQWIENYSTK VKFLYEKLSQ GGLVKWDEKD
DKHLKALQHD LVNAPVLSLP DLKRPFYLFV NTDSGTAYRV LTQEWAGKKK PVGYLSKLLD
PVSRGWPTCL QALVACALLV EEANKITFNG ELRVLSPHNI RGILQQKAEK WITDARLLKY
EGILLDSPKL TLEVTALQNP AQFLYGRPSE DGLAHECLST IEEQTKIRPD LDEEELEEGD
RLFVDGSSRV INGKRVSGYA IVAGEGLAVI ESGPLSGSWS AQACELYAVL QALQLLKDKS
AAAARRARRR HFPAKLWSLA NDPRVLSVRW DSEARGLLVD RSLFERELLR PGGAQGPAPH
AFRATQFRSF VRQLYRYGFR KVPGRAGAAA PGDAGAWLHY TNPWFRRDRP DLLLRIRRRS
AANTQRRAAG PEGRRRPPCG SQQLPGPRPL PDERHGRARF QPLPRERPPL ARRPPCGFHL
LHRERPGPAR REGPSRFQEL YGERPLPAER ELLRVPPCHF QGFHGEQLLP PRWEGPRSRM
QELYGEQPPP LDRELLWMQP CSFQQLHREQ QPPASNPPAA VGTSAPHAPA GSAGCAASTA
SSSAQNAPAQ EESPALDLGQ EIEKMIREIR NSLPVKAPSA QGNINVAPES PGEDPMNRAA
AEEVSAGTES CRNSSPEPEE PVKKPDGSYR LVQDLREVNK RTRSRYPVVP NPYTLLSKVS
PQHQWFSVVD LKDAFWACPL AKESRDIFAF EWEDPKTGRK QQLRWTKLPQ GFTESPNLFG
QALEKILQAF STPPRIQIIQ YVDDLLLSGE DEVEVREATI KLLNFLGEKG LRVSKGKLQF
VEPEVKYLGH LIKKGVAHGV LVQEWEGVKR PVAYLSKMLD PVSHGWPVCI QAIAATAILV
EESHKLTLGG KLIVCTPHAV RNELNQKAEK WLTDSRMLKY EAILIDSDDL TLEVLLTTEA
AIRTKERGWI HASRIKGPVE EPKEWTITSE PGDTKLTLKW GLGGNELGRP KWSKKHTQDH
T
//
