ID A0A3M0IP59_HIRRU Unreviewed; 1339 AA.
AC A0A3M0IP59;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=SETB1 methyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_32982 {ECO:0000313|EMBL:RMB90717.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB90717.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB90717.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB90717.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB90717.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB90717.1}.
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DR EMBL; QRBI01000246; RMB90717.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0IP59; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd10517; SET_SETDB1; 1.
DR CDD; cd20382; Tudor_SETDB1_rpt1; 1.
DR CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR040880; DUF5604.
DR InterPro; IPR025796; Hist-Lys_N-MeTrfase_SETDB1.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR Pfam; PF18300; DUF5604; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS51573; SAM_MT43_SUVAR39_1; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 647..718
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 780..853
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 856..1314
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1323..1339
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 155..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6..81
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 410..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..961
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1339 AA; 149248 MW; B952483BCAA81CAD CRC64;
MDSPDIKELQ QEVEELGISM EELQEIIDKE VENSEWVRQR KQQLEELEQC MRHKEEEVAH
VDQLIDDAMR AINKCETLAK ELYSMMGLQY RESSSEDEAP AAAEVIEIAD EEDDDVMSVD
SGWKHSSLRE AMAAMRKSAR DVAKFMDAVN KKTNLQEAQK DAQPPQEPPG TAQPVTVPAT
PGNDLNTDGD LKVGMRILGK KRTKTWHKGT LIAIQTVGAG KKYKVKFDNK GKSLLSGNHI
AYDYHPSAER HHVGRRVVAR YKDGNQMWLY AGIVAETPNV KNKDRFLIFF DDGYASYVKE
WELYPVCRPL KKAWEDIEDV SCRDFIEEYI TAYPNRPMVL LKSGQLIKTE WEGTWWKSRV
EEVDGSLVKI LFLEALPMGT VNVSFFPQED KRCEWIYRGS TRLEPMFSMK TSTASTQEKK
QSGQTRTRPN VGAVRSKGPV VQYTQDLAGA GPQYKALEQP PAARPASPQP VEMDLPSSFP
SQLFHRKGSS AAVSQVPVLS VSRGGDFATF QSLTTQVLLA TPWPVRASLP SSVPASQLFR
RKGSSAAVSP SATRTCVLSV SRGGDFTTFQ SLTTLLATPG WCPPHPHLPS PLSLPSSVPA
SQPFHGMMDR VPNEPSYRAP LEKLFYLPHV CSYTCLSRVR PLRSDQYRSR NPLLIPLLYD
FRRMTARRRV NRKMGFHVLY KTPCGLCLRS MHEIERYLFE TDCDFLFLEM FCLDPYVLVD
RKFQPYKPYY YIADITKGKE DVPLSCVNEI DNTPPPQVAY SKERIPGKGV YINTSWEFLV
GCDCKDGCRD KSRCACQQLT IQASGCTLGG QINPNSGYQH KRLEECLPTG VYECNKRCKC
NVNMCTNRLV QHGLQVRLQL FKTQNKGWGI RCLDDIAKGS FVCIYAGKIL TDDFADKEGL
EMGDEYFANL DHIESVENFK EGYESDAKCS SDNSGVDLKD DDDNENTGTE ELEESNEDSS
DDNFCKDESF STSSVLRSYA TRRQTRGQRD HGHSETASKD SGLARPPGHE EPAAAPPCKL
PVSEETSKHK VASWLSSNSM AEGFQDSDGA PCFRAGGEGG EGKAVKMEMA AEREKGCAGA
LGDLNGEAKA AKKEEPDEAT KMPGLSSLGR RYGYNPCPPK LDGIRRPVGG TVLLQSRRRS
LALPPPLEDV LTLSSSTDTD EEQRAGQPTG QQDSDDIQTI SSGSEEEEGE DKKNQSSGSG
PVKRQVAVKS TRGFALKSTH GIAIKSTPLA AADKGESAGP VRRSTRQFYD GEENCYIIDA
KLEGNLGRYL NHSCTPNLFV QNVFVDTHDL RFPWVAFFAS KRIRAGTELT WDYNYEVGSV
EGKELLCCCG AIDCRGRLL
//
