ID A0A3M0IYY2_HIRRU Unreviewed; 826 AA.
AC A0A3M0IYY2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=DUI87_31949 {ECO:0000313|EMBL:RMB91719.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB91719.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB91719.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB91719.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB91719.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB91719.1}.
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DR EMBL; QRBI01000235; RMB91719.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0IYY2; -.
DR STRING; 333673.A0A3M0IYY2; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002248; Cl_channel-6.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01117; CLCHANNEL6.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 197..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 284..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 328..352
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 476..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 764..825
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 826 AA; 92630 MW; 3271B01C82195847 CRC64;
MARCGAGLCC CCCCGERESR TPEELTILGE THEEEDEILP RKDYESLDYD RCINDPYLEI
LESMDNKKAQ RYEAVKWVLV FAIGVCTGLV GLFVDFFVRL FTQLKFQPVA AGSGIPEIKC
YLNGVKVPGV VRLRTVVCKA TGVLFSVAGG LFVGKEGPMI HSGAVVGAGL PQFQSISWRK
IQFNFPYFRS DRDKRDFVSA GAAAGVAAAF GAPIGGTLFS LEEGSSFWNQ GLTWKVLFCS
MAATFTLNFF RSGIQFGSWG SFQLPGLLNF GEFKCPESDK KCHLWTAVDL GFFILMGIVG
GLLGATFNCL NKRLAKYRMR NVHPKPKLVR VLESLLVSLT TTVVVFIASM VLGECRQMSS
SRHSGNDTLS LQDISEDVNS SIKTFFCPNE TYNDMATLFF NPQESAILQL FHQDGTFSPV
TLSLFFLLYF LLSCWTYGIS VPSGLFVPSL LCGAAFGRLV ANLLKSYIGL DHIYSGTFAL
IGAAAFLGGV VRMTISLTVI LIESTNEITY GLPIMITLMV AKWTGDFFNK GIYDIHVNLR
GVPLLEWETG VEMDKLRASD IMEPNLTYVY PHTRIQSLVS ILRTTVHHAF PVVTENRGNE
REFMKGNQLI SNNIKFKKSS ILTRAGEQRK RSQSMKSYPS SELRNMCDEH IATEEPPEKE
DLLQQMLERR YTPYPSLYPD QSPSEEWTME ERFRPLTFHG LILRSQLVTL LDRGVCYSES
QSSASQPRLS HAEMSEDYPR YPDIHDLDLT LLNPRMIVDV TPYMNPSPFT VSPNTHVSQV
FNLFRTMGLR HLPVVNAVGE VVGIITRHNL THEFLQARLR QHYQTI
//
