ID A0A3M0J2K5_HIRRU Unreviewed; 1282 AA.
AC A0A3M0J2K5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Double-stranded RNA-specific adenosine deaminase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_28538 {ECO:0000313|EMBL:RMB94995.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB94995.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB94995.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB94995.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB94995.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB94995.1}.
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DR EMBL; QRBI01000191; RMB94995.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0J2K5; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR CDD; cd19914; DSRM_DRADA_rpt2; 1.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044456; ADAR1_DSRM_1.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 236..302
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 337..401
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 553..621
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 668..736
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 784..852
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 921..1277
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 162..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..36
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 305..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1282 AA; 141799 MW; CF3821E3498A0627 CRC64;
MQNVMYDLIT ELNDRSEDLE KQISGLESKL EQLSASFNSL PLLMADMLRQ QQQRLLAAVL
EARGVRPFPP GQLNRVGECG VSDSSSPGSS AARFPRVSQD CAMIRGTGRG RGLYLTQSNR
NFPSTNRGLF NHPCTPRETN QESFLHQQFL TEQDAEVSVL QGQGSHKESR TRGGRAVAPA
PANRCQPSSS RAGWRKFSSQ HPWVETLSRC CPPQYRCQEN YRRDSDTVRL NFQRLSLAGQ
DYEQEILTVF RQLGEGRTCT ANDLARKLKT QKKEVNRVLY KLLREGKLHK GGETPPLWRI
ASPSSGRERS PTDHSASCTD PACESRGEEQ NTLGSGHTEM AETKEKICNY LFSVMETTAL
NLAKNIGFSR AKDVNAFLSA LEKLGDVHKQ NAIPPRWSLT NRKREKMQMR LKASTTMQMA
DSTPSEAGHP SSFVPPCPPE MTATSPEVMA SEESVENGQQ PLGQAGQGHV SDKKAEASGD
IKPEFSSLSN YDNSENSKWI TDDIPDNLNT MNKQPEKSEC IMNSQSSPSY AAPFETAFPC
TPVEKLLACQ EKNPVSGLTE YSQYTYQHCD FIMLEQNGPS HEPRFKFQAV INGRRFPPAE
AGSKKLAKQE AAANAMKVLM SEVENGRHSE IKCDEPFPSN SMEPELPLQL EPEQSSTAAH
LNLLPGKHPI SILMEYGQKS GNIIEFQLLS QEGPPHDPRF SYCVKMGDQT FPAVVGNSKK
GAKQMAAEVA VKILSGESVP HLSSEQPVVK PHSNQSMHNI ATPDESKVVK TKGVGELIKY
LNVNPVSGLL EYARSNGFAA EFKLIDQSGP PHDPKFVYQA KVGGRWFPAV TAHSKKQGRQ
DAADAALRVL IGESEKTEHM EEMSITELPV SGSTLHDQMA MLSHQRFNAL TARIQHTLLG
RKILAAIIMR RGKKGLGVVV SIGTGNRCVK GEELSLKGET VNDCHAEIIS RRGFVRELMK
YDPSNPSSAE ESIFEQAGGK KLRIKSSVTF HLYVSTAPCG DGALFDKSCS DQANEMGQPQ
HQPLFENSKQ GKLRTKVENG EGTIPVESSD IVPTWDGIQH GERLRTMSCS DKILRWNVLG
LQGALLSHFL EPVYLHSVTL GAKLSLSFQG YLYSQGHLAR AICCRVDRDG STLREKLQAP
YHINHPEVGR VSVYDSARQT GKTKESSVNW CLADESEVEV LDGTKGKVDG VPSLTAATVF
LLSLKLEVSR VSKRKMFTLF RQLCAKNSRR DLLSFSVYSD AKEAATAYQA AKQCFYSTLE
ELGYGSWIRK PQEEESFSVL DA
//
