ID A0A3M0J8W2_HIRRU Unreviewed; 4396 AA.
AC A0A3M0J8W2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Protocadherin Fat 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_26765 {ECO:0000313|EMBL:RMB96700.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB96700.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB96700.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB96700.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB96700.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB96700.1}.
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DR EMBL; QRBI01000172; RMB96700.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0J8W2; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 32.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00232; CADHERIN_1; 10.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..4396
FT /note="Protocadherin Fat 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018008217"
FT TRANSMEM 4082..4102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..151
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 152..259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 366..461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 462..567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 568..716
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 718..822
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 823..931
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 928..1034
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1043..1144
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1140..1245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1246..1338
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1353..1450
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1451..1556
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1557..1661
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1662..1759
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1768..1873
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1970..2071
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2072..2172
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2173..2273
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2274..2380
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2381..2482
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2483..2586
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2587..2693
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2694..2799
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2800..2907
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2908..3012
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3013..3114
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3115..3219
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3220..3324
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3325..3429
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3430..3534
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3535..3622
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3775..3947
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3949..3986
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3988..4024
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4026..4062
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4244..4270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4367..4389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4250..4269
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3976..3985
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4014..4023
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4052..4061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4396 AA; 483599 MW; D03693385155CCCD CRC64;
MEVSIRSHFL SVAVFLMHCV LHKASCEKGN TSTLHFTHSF YNATIYENSA PKTYVESYVK
MGIYKGHPEW DIRYRIASGD TTGLFKTEEH VIGDFCFLRI RTRSSNTALL NREVKDSYML
IIEAIESTFA SKAWAKVLIH ILDRNDLKPL FSPPSYKVSI KEDTPLKTVV STLSATDADA
GQNAEFYYAL NTKSNLFTVH PTTGAVMVTG RLNSTHRGRH NLQVLAVDRM RKITEGNDFG
NLASLTIQVE PSARKPPSIS SVKVTSPDSD EDFIYATLSV ESGDSEAGID SVEFVDGDPG
RHFKAIRSYF GSSEFMIVSN KEINWLLYPF GFNLSVQAKD KSKPPLLSPV RVVHIPPSKY
VSARFEKEVY QVQLSEFSPA GSQVVMVKIT PVFPNLKYVL RPTPDSTSFK INPHTGLITT
VRAMDFHEQS SFELEVTTSN SHTSTTVIVD ITDCNNHAPS FTQSSYHGAF DENVPPGTSV
LTVRATDEDK GDNGFVTYSI ANQKSVPFVI DPYSGVISTS KSMDYELMQR WYHLRVWASD
WGSPFRHETE VYVSLTLSNV NDNAPVFEKA SCSGTIPRDF PVGSPVATVS AIDSDELQHI
KYEIKSGNEL QHFELNPISG VISLRISLRD LPSEQPLFYS LKITATDGEN YAFPTSVNIT
VVSQGLPVKM QCEETGVLKQ LTETIIHSIE SQSQGHGQDD ETSLNLHLIN HNAPKFDDSF
PRSIDIVETV PINSTIADLS AIDPDTGFNG KLVYVISDGN DDSCFTIDLE LGLLQVLSPL
DHEQTSFYIL NITVYDLGTP QKSSWKLLAV NVLDTNDNTP KFPQGAYWVS IPEHVAAGTT
IAQLKAEDAD TDDNGRVKYS LLTPTDKFAI NSVTGEVMVT GALDRELWPC YVLKIEARDQ
PKTGFQLFSV ADLVVTLEDV NDNTPQCLPA LNSVKVPEDL PVGTILLFLE AFDPDSGSGG
EVRYSLINNE EMMFHVDKLT GALRLEKELD YEKRDSYNLT VQVSDGGKPF SRSSLCHLEV
NVIDVNENLN PPRFASFVFK GWVQENSPKG TSVMMVMAKD IDRGKDGEVQ YFLREGTGLS
VFHIEKDTGI IRTMGSLDRE GTSHYWLTVL ALDLGTIPLS SVTEIYIEVT DTNDNPPQMS
RPVFYASVME NSPPNTSVLQ LDAYDPDSSS EGKLTFHILT GNPQGLFTIN LITGLISTTS
QQLDREYKAE HILEVAVSDN GEPALKSTSR VVIQVLDAND SPPSFPHKLF MVQLPEREAS
ETPLPVYRLI ASDRDQGQNS QITYTIEEEE EGIFTINPTT GTIFSRKAFP ASEYNILTVK
ATDGGSPPLS SHVRLHISWV ARPGPSSEPL AFDEPHYNFA VMETDPVNHM VGVISIEMGP
SQVWFNITGG DDDMDFDIEK STGSMVIARP LDARKKSSYN LTVEVTDGSS TIKTQAFIHV
IAINQHRPQF LESHYEVRTP EDTPAGREIL RVSATDKDKG KGLIYTIHGS VDPKSTRLFQ
LDPSSGALTT AEGFSSQPMP QHTLTVMVRD QEIPIKRNFV RVIVRVDSCN LHPPQFSSIH
YEAQVLDLAV VGTEVIQVRA LDEDQGANAE IHYSLQAGNG EGFFSIDPYS GIVTVARKLD
PSRQERFTLI VKAENQEFPQ LKDSATLHVH VRPSDRTPPK FPEAEYITEI SESTAVGSPL
IQVSATSLSP VSYEIKDGNG GGVFSMNYQS GLISTQKSLD FEQVSFYQLK IRGTNMAGAF
MDTVVFIYVI DENDNVPVFV KPSFVGWIME NAPSQSMVLD ESNAPLVTYA TDADQDSNAL
LVYEILEPEA LKYFTVDPST GTLTSRADID YELTPVFHFS VHVHDSGSPS LFASKPAKVT
IHVKDVNDSP PVFLRDIYDI SVLLPAHPGM ELLSVQAKDA DSEVTYSIVE GNLDNAFHIH
PLTGLISILN TTGLRSFREL TVRAGDGLYK STALVKLNLT RAQGTSLKFD QDIYTATVME
NSTDEKTLTI LGVKGYQLNE PLSYSLLNEK ERFKMIQASG VLQTKGVKFD REVQDVHEVA
VEVKDNRKPP RVSQATVRVY VEDVNDNPPQ FENVPYYASV QDGTEPGDVL FQVSATDKDI
GANGAVTYSF AEEYKYFWID PYLGDISLKR PLDYQALNKY NLRIIAKDKG EPPLHAEEEV
VISVRNRSNP LFQSLYYRVK VPENVPPYTS ILHIQARSPE GLRLIYNIVE EDSLKLFNTD
FKTGVLTVTG QLDYELETKH TFTVRATDTA LGSFSEARVE VEVEDINDNP PIFSQIIYTA
SVSESLPPQT PVVQLFASDK DSGRNKVVSY QILDDGSEAA KFFNIDASTG QITTAQALDY
ETNQQFRMKV RAADHGVPPL SSDALVIVDV TDINDNPPEF SQLQYEAKVS EMATCGHIVI
KVQALDPDSG DTTRLEYVIL SGNDNRHFAI NSTSGIISMF NRCKKDLEPS YNLRVSASDG
VFKSTVPVYI NTTNANKYSP SFQQNVYEAE LAENAEIGTK VIELLAIDPD GGPYGTIDYT
IINKLAHEKF SIDNKGCIAT LQKLDRENST ERVIAIKVMA KDGGGKVAFC TVKIILTDEN
DNPPLFKASE YTLSIQSNVS KGSPVIQVLA YDADEGANAD VIYSVDSVED VAEDLVEINA
ATGVVKVKES LIGLENRAFN FKVKAEDGRP PHWNSLVPVN LQIVPREVTL PRFSEPLYTF
SASEDLPEGS EIGSVKAFAE DPIIYSLVKG TTTESNKDEV FTLDEQTGAL KIKKPMDHET
TKWYQVDVMA HCSHLETELV SLVSVNIQVQ DVNDNRPVFE ADPYRAFVME NMPSGTTVIQ
VTANDQDVGS DGQVTYSLES ESGNLRGLFT IDGESGWITT LKELDCEDQE TYRFYVVATD
HGRKVQLSSQ TLVEVTVSDE NDNAPQFTSD FYKGSVIENA EPGQVVVTLS TVDADISEQN
RRVTCYITEG DVLGQFTVDQ IEGEWTISSK KPLDREDTEK YLLKVMASDG KFQATTEVEI
FVLDINDNSP ECGQILYTGR VSEDAGPGLF ILKISATDPD VGSNAQITYS LHGPGAEEFQ
LGPHTGELTT SAPLDREQKP TYHLVAKATD GGGRSCQADV TLIIEDTNDN APRFFPSHCA
VAVFDNTTTK TPIAVVAARD LDEGLNAEVV YSLPDSANGH FSIEETTGVI RLEKPLKDSQ
HSAFELTVCA TDRGTPEPLS SLGTVTVSVV DLNEYLPVFL APEYVAMVKE DVAVGTEVLN
LSALTRDNAE NTEIKYEIVN GNDHGKFQLN SNTGALYING SLDFEASHEY YLSIEGTRKG
SASLSDVTMV VINITDINDH APEFIQDPYF TDIREDAAIG EIILTVSADD LDGSMNNQIT
YSIVEGNPLG HFAIQPKNGQ ISIAKHLDRE EISSYSLTVR ATDNGHPAQF SDVPVHVLVS
DVNDNPPRFF QLNYSVVVQE NAPVGTSVLE LIMSDRDSPE NGPPYSFQIT QGNDGKAFEV
TQNGLLVTSS VLNRRMKEQY LLQVQVSDSG IPPLSSSAFI NIQVTEQSQY APSALPLEIF
ITTNEEAFRG GVLGKIHATD RDPHDTLVYT LVAQAPKEGL FSVGAADGKI IAGDKLPHGH
YLLNVTVSDG TFTATTSVSV HVWCFTQEAL DKAVVLHFRH LSPEEFVGDH WRNLQRFLGN
ILVTRRQNIH MASLQPAAAS DGVDLLLAVG EPHGSLYEPR VLANKLTVSA GEMDQLVGLR
MKKAIHVPCH GPDCAHRVCK ETIQLDPGMM STYSTARLSV LTPRHSLEQI CSCNGTAVRF
GGHSYIWYQH SQVGSWHMHF RLKTHQHHAV VFYANGTDHA TLEMVNGVPQ LGYSCRGSPS
GNLSSSRFVS DGEWHSVFLE VKNTSVRLLV DGLGNASLQL PGTCSTSQGR RDLIFGGLRQ
SLQSQRVTRG FRGCLDVVAI NGREVVLLPG KGQSKEVLEE VGIKQCCSPS GACRSNPCLN
NGMCSETHGG GYTCICPGLF SGEHCELGDS PCESKPCLHG GTCTLSATGY SCHCPDWYLG
ERCEKLAEEC QDNPCRNAGR CVSSQGSVHC ICPSDFQGDY CTQPIITPAI VPTQWALGPQ
EIAEIAAGVL GAAILAAVFV LVRKRCRRRA KEHKPVARED PDLLSKSEFS KSVGVGTQPV
PPIELNILSD AAHNNLDRAA PEQRKATGTP EFVTFNSANA PKHRGTIVCS VAPNLPPAAP
PSNSDNESFV KCTWAREEMV YPAETTYWPP RYVSSDVQEY SHYEIIPGPP ASSSHPPLPP
PPPPPADTEP VALYGGFPFP LDQSNKRAPI PPRYSNQNLE DFLPLGPVDM GASQCQNEYT
AISYYPAQLV QGEGVPYQPE PGYKRVSMRL SVAQPSYADC ELGHQPSIRA QPLPPPNYEG
SDMVESDYGS CEEVMF
//
