ID A0A3M0J9V1_HIRRU Unreviewed; 1265 AA.
AC A0A3M0J9V1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RMB97030.1};
GN ORFNames=DUI87_26477 {ECO:0000313|EMBL:RMB97030.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB97030.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB97030.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB97030.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB97030.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes viral DNA integration into the host chromosome, by
CC performing a series of DNA cutting and joining reactions.
CC {ECO:0000256|ARBA:ARBA00003235}.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB97030.1}.
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DR EMBL; QRBI01000170; RMB97030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0J9V1; -.
DR STRING; 333673.A0A3M0J9V1; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 1.10.1200.30; -; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 1.10.375.10; Human Immunodeficiency Virus Type 1 Capsid Protein; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR045345; Gag_p24_C.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR008919; Retrov_capsid_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF00607; Gag_p24; 1.
DR Pfam; PF19317; Gag_p24_C; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR SUPFAM; SSF47943; Retrovirus capsid protein, N-terminal core domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00450};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00450}.
FT DOMAIN 402..596
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 816..952
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 957..998
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 1006..1168
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1180..1227
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 1180..1227
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT REGION 390..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1265 AA; 138867 MW; EEB8648FB9E3D93D CRC64;
MQVLRSFNVS LLTPFDIRSL ARALFPPVEY DFFENKWTQL AVRAVEWNTT LGPGDPRRMV
NIDMLMGTGN YTRAEGQAGY EPLVQEQCQQ TGMAALVQTL QLATPQQPFA TIVQGVDEPF
LCFAGRLTAA VEKQVSDPAA RKLMIQSVAQ GNCNAACKRI IEALPGEPSM SDMVGACAKI
SPSSQQVVAV HTAVQPAVAT IVQPTVATAV QPAVPAAVQP AVAAAVQPAW VVPQGVQQQQ
WGARARKKQR KAQKPTAVLF YCARCGRPNH AANACKATVH VNAPTNGDLL SRLAASTRGS
AGVDVCTAES VVIDSDKIRK VPLDAFGPLG DGMSAFLMGR SSATIQGIIV HLGLIDADFS
GQIHAMVSTP TPPLTIPKGT RTAQLVPFKS SVSRTEDRSR GDGGFGSTGP PQVRWTAVLT
KDRPETLCTV SMVAATPSEI HLRGLLDGMV ASLQAGMPSP TMLPADWLVL IVDLKDCFFT
IPLHPDDRPK FAFTVPTINN AEPAQRYQWR VLPQGMRNSP MLCQWYVARA LSGVRKRFPG
AHVYHYMDDI LVATPTQEEL LRLQPQLLNA LHSHGLQVAP EKVQQQPPWK YLGVKILERT
IRHQEVQFVQ SVKTLNDAQK LVGVITWLRP YLGLTTAQLS PLFELLKGDT DLKSPRELTP
EARKVLEEVQ QAVSACQVYR IEPSIDVTVF ITTPDLHPTG IIGQWNDDWT DPLHVLEWVF
LPHQPHKTAT ALFELIARLI IKCRQRCLQL MGADPSKIIL PVQREEFDWS YANNVSLQSA
LEGFSGQITY HLPSHKLLQV AKNTQFSLRP KSSQEPVQGP TVFTDGSGKT GKAIVTWQDG
SEWQVLEGHE DGSAQLVELK AAVMAFEKFS QEPFNLITDS AYVADIAQRL SCSVLKEVSN
PALFDLLKAL WCAIQARVHP YYVLHVRSHT NLPGFVAEGN ARADKLANPA WVAPQPDVLA
QAKASHGFFH QNAHTLQKQF QLTATEAREI VESCDDCHAL GVPLPAGVNP RGLKALELWQ
TDVTQVAEFG RLKYVHVTVD TFSSAMWASA HTEEKARDVI AHWRQAFAVL GIPSAVKTDN
GPAYASQQVR QFLQSWGVSH NFGIPHSPTG QAIVERNHGT LKCVLQKQKQ GMQGETPKSR
LAKALYTINH LTVPQNSNNP VILNHHLSLQ ASDGEQQPRA KARVRNLVTK QWEGPYDLIA
MGRGYACVST DTGTRWLPSK CVRPDLRPQR QNSADRQGGS RDQLESHQVD ESSSDHSDDS
STDSD
//
