ID A0A3M0JB37_HIRRU Unreviewed; 765 AA.
AC A0A3M0JB37;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN ORFNames=DUI87_25512 {ECO:0000313|EMBL:RMB98034.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB98034.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB98034.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB98034.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB98034.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB98034.1}.
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DR EMBL; QRBI01000154; RMB98034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0JB37; -.
DR STRING; 333673.A0A3M0JB37; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF2; AMP DEAMINASE 3; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221}.
SQ SEQUENCE 765 AA; 88863 MW; 0E5571DC7F289EA7 CRC64;
MPRQFPKLNI SEVDEHVRLL AEKVFAKVLR EEDSKDALSL FTVPEDCPIG QKEAKERELQ
KELAEQQSVE TAKRKKSFKM IRSQSLSLQI PPQEWKAPPA NPVLSPATPV LPSAFVPVQV
PYDVPEFQRV SISGDYCAGV TVDDYEQAAK SLVKALLIRE KYSRLAYHRF PRTTSQYLCS
MRDQKWKVED EVHPVFHSPP EENEDPYNLD DAPDNLDYII KLQGGIPFVY DNKVMMELNE
PRSLPYPDLQ TYTLDLSHVL ALIADGPTKT YCHRRLNFLE SKFSLHEMLN EMSEFKELKS
NPHRDFYNVR KVDTHIHAAA CMNQKHLLRF IKHTYQTEPD RIVAEKKGKK MTLKQVFESL
HMDPYDLTVD SLDVHAGRQT FHRFDKFNSK YNPVGASELR DLYLKTENYI GGEYFARMVK
EVARELEESK YQYTEPRLSI YGRSPDEWLN LAKWFIKHKV YSPNMRWIIQ VPRIYDIFRS
KNILPSFGKM LENIFIPLFE ATINPKDHKE LHLFLKYVTG FDSVDDESKH SGHMFSDKSL
NPDLWTSEKN PPYSYYLYYM YVNIMLLNNL RKERGMCTFL FRPHCGEAGS ITHLVSAFLT
ADNISHGLLL KKSPVLQYLY YLAQIPIAMS PLSNNSLFLE YSKNPLREFL HKGLHVSLST
DDPMQFHYTK EALMEEYAIA AQVWKLSTCD LCEIARNSVL QSGLSNKEKQ KFLGVNYCKE
GPEGNDIRKT NVAQIRMAFR YETLCNELSF LADAMRTEDI STLSK
//
