ID   A0A3M0JCE7_HIRRU        Unreviewed;       682 AA.
AC   A0A3M0JCE7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Rho guanine nucleotide exchange factor 37 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DUI87_26637 {ECO:0000313|EMBL:RMB96573.1};
OS   Hirundo rustica rustica.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC   Hirundo.
OX   NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB96573.1, ECO:0000313|Proteomes:UP000269221};
RN   [1] {ECO:0000313|EMBL:RMB96573.1, ECO:0000313|Proteomes:UP000269221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Chelidonia {ECO:0000313|EMBL:RMB96573.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:RMB96573.1};
RA   Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA   Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT   "A high quality draft genome assembly of the barn swallow (H. rustica
RT   rustica).";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMB96573.1}.
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DR   EMBL; QRBI01000172; RMB96573.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0JCE7; -.
DR   STRING; 333673.A0A3M0JCE7; -.
DR   Proteomes; UP000269221; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd07589; BAR_DNMBP; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11799; SH3_ARHGEF37_C1; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR035823; ARHGEF37_SH3_C1.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR   PANTHER; PTHR22834:SF9; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          30..215
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          256..454
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          508..571
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          609..672
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
SQ   SEQUENCE   682 AA;  76182 MW;  21AC1FBD9172AAAC CRC64;
     MASAEPGSED AAEAEEAVYE AMPCDRTELS QRLAVEELIA TEASYVHNIQ LCVCDIRAHL
     QKKQLPELDL EGLFSNTDDI LHVSRRFLKA LEATAGQGQE QLHSISTLFQ EFKEEMEAVY
     KIYCASYDHA LQLVESYRRE PRLQEEILDT LNATVPHTGA SDLSFFLVMP VQRVTKYPLL
     LGKILENTPS SASAHSALQA AARAMAQVNA NINEYKRRRE VATKYNKAEH LTLRDRLARL
     NTHSIAKKTT RLSRLLMHEA GIVAKTEDKE YDDLEEKFQC VASSVATLKE NVASYLGHFE
     AFLLPAPHRC DLQVDEGPAL QHRRLSELLR GTVFPEFKRR VDRLVWQPLC SLSDTLEGPQ
     QLVKKRLDKL LDYEEIQERK SELGSVSYEE EAAMNTYLAI NDLLVAELPQ FNRVAVQLLG
     QILRSFSALQ LDLAAQVLHH AEKELEQLPH GHMPLPSFWK VVEDTLQQSG AQLRAFCQAF
     DTVTPSPGTE PLTPAEERKV LSLVSKHGPD KLYQVTSNIS GSRDLDLTLL RGQIVALLQS
     ADTKGNTGRW LVDAGGPRGF VPAAKLRPYS PAQVQQPGMD LLTLDSGTER RRHSYQFPEA
     PRPQVATFTP TFQVVAGFSF AARSPQEVTL QAGQPVLVLE PHDKKGSTEW SLVEVNGQRG
     YVPSSYLVTV PVREPAGWSL PV
//