ID A0A3M0JEG2_HIRRU Unreviewed; 1169 AA.
AC A0A3M0JEG2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RyR/IP3R Homology associated domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_24097 {ECO:0000313|EMBL:RMB99361.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB99361.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB99361.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB99361.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB99361.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB99361.1}.
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DR EMBL; QRBI01000149; RMB99361.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0JEG2; -.
DR STRING; 333673.A0A3M0JEG2; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF1; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 189..325
FT /note="RIH"
FT /evidence="ECO:0000259|Pfam:PF01365"
FT DOMAIN 864..969
FT /note="RyR/IP3R Homology associated"
FT /evidence="ECO:0000259|Pfam:PF08454"
FT REGION 135..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1169 AA; 132080 MW; BD4E95C847D98FE3 CRC64;
MLEVDDEGGR MFLRVLIHLT MHDYPPLISG SLQLLFKHFS QRQEVLHTFK QVTLRGPGAP
HAWPWVGDVG WIPALSLGGK SGSGICAPNW KPLGMSLQVQ LLISAQDVEN YKVIKSELDK
LRTMVEKSEL WVDKKGSTKG DSAGEGNKKE KKEHGADEEV IAPGEKSSEN YQIVKGILER
LNKMCGVGEQ VRKKQQRLLK NMDAHKVMLD LLQIPYEKGD AKMMEILKFT HQFLQKFCAG
NQENQALLHK HLNLFLTPGE TMQHIFLNNY QLCSEINETV PQHFIHCVAT HGRHVQYLDF
LHTIIKAEGK YVKKCQDMIM TELTNAGDDV VVFYNDKASL ATLLEMMTAA RDGVEENSPL
MYHISLVDLL AACAEGKNVY TEIKCTSLLP LEDVVRVVTH EDCITEVKMA YVNFVNHCYV
DTEVEMKEIY TSNHIWTLFE NFTLDMAQMC KKREKRLPDA TLEKYVLTVV LDTINAFFSS
PFSENSTSLQ THQTIVVQLL QSTTRLLECP WLQQQHKSSV ESCIRTLAMV AKSRSIALPM
DLDAHVSSLL NSSSTSTVPR NTSSYKAATR TFPRVSATPN QWDYKNIIEK LQDIINALED
RLKPLVEAEL SVLVDVLHRP ELLFMEGTEA FQRCESGGFL SKLVQHTKDL METEEKLCIK
VLRTLQQMLV KRNKYGERGN LLRKMLMNNY LQNKRSSSKG EMGDAAGGGQ DQDWSAIAAV
QCRLDREGAT KLVADLIMNT KNEKIFQESI LLAIRLLDGG NTEIQKSFYN LMTSDKKSEK
FFKVLHDRMK KAQQETKSTV SVNMSDIGNK PREDKDEPDP GTKGRGDTFL MPGTPTRYPM
AVGFRKGHEP GEQGQNNEMG VTVLIMEPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV
CETLQFLDIM CGSTTGGLGL LGLYINEYNV ALITQTLETL TEYCQGPCHE NQSCIVTHES
NGIDIITALI LNDISPLCKY RMDLVLQLKD NASKLLLALM ESRHDSENAE RILISLRPQE
LVDVIKKAYL QEEECENAEV SPREVGHNIY ILALQLSRHN KSLQQLLKPV KRIQEEEEEG
ISSMLSLNNK QLSQMLKSTA PVQEEEEDPL AYYEKHTSQI EARPLGCLLS SLPTVQESHL
APDASCPVIL HQELRPLPTP KLAAPGTEA
//
