ID A0A3M0JH71_HIRRU Unreviewed; 4492 AA.
AC A0A3M0JH71;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Ryanodine receptor 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_23041 {ECO:0000313|EMBL:RMC00432.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC00432.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC00432.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC00432.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC00432.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC00432.1}.
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DR EMBL; QRBI01000144; RMC00432.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0JH71; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 3.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 3898..3922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4292..4314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4373..4396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..142
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 176..230
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 236..293
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 547..758
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 974..1170
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1162..1368
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3642..3670
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 2160..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4048..4093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4048..4083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4492 AA; 510120 MW; E7DBDA4275183CDB CRC64;
MECQDDEVVL QCVASIHKEQ RKFCLAAEGL GNRLCFLEPT SEAKYVPPDL CVCNFVLEQS
LSVRALQEML ASTGDNASEG AAQGGGHRTL LYGHAILLRH SFSEMYLTCL TSSRSQTDKL
AFDVGLRENA AGEACWWTIH PASKQRSEGE KVRIGDDLIL VSVSSERYLM KQKRDKGFLL
GGHVVRFFHG HDECLTIPST DQNDSQHKKV FYETGGAGIR ARSLWRVEPL RISWSGSNIR
WGQPFRLRHI TTGKYLALNE DEGVVILDRE KSDTASTAFC FRASKELKEK QESSLKRDID
GMGVPEIKYG DSICFVQHVA TALWLTYKAQ DAKSARLGPL KRKVILHQEG HMDDGLTLQR
CQREESQAAR IIRNTTSLFS HFISGNNRAL SPTALPVEEM AQTLQDLITY FQLPEEDLQH
EDKQNKLRSL KNRQNLFKEE GMLALVLNCI DRLNDYNSAA HFAGIVREEH GGTSWKEILN
LLYKLLAALI RGNRNNCAQF SCNLDWLISK LDRLESSSGI LEVLHCILTE SPEALNLVSE
EHIKSIISLL DKHGRNYKVL DVLCSLCVCN GVAVRANQNL ICDNLLPRRD LLLQTRLIND
VTSIRPNIFL GVAEGSAQYK KWYFELIIDQ VDPFLTAEPT HLRVGWASTS GYAPYPGGGE
GWGGNGVGDD LYSFGFDGLH LWSGRVPRAV ASVNQHLLAS DDVVSCCLDL GVPSISFRIN
GQPVQGMFEN FSTEGFFFPV VSLSAGVKVR FLLGGRHGEF KFLPPAGYAP CYEALLPKEK
MKLEPVKEYK RDFEGVRDLL GTTQFLSQAS FIPCPIDTSQ VALPFHLEKI RDKLAENIHE
LWGMNKIELG WTYGKIRDDN KRHHPCLVEF SKLPETEKNY NLQMSTETLK TLLALGCHIV
HAHPAAEEDL KKVKLPKNYM MSNGYKPAPL DLSEVKLLPS QEFLVDKLAE NAHNVWAKDR
IKQGWTYGIQ QDLKNKRNPR LVPYALLDER TKKSNRDSLR EAVRTFAGYG YSIEPPDQEI
ADQTVEKVSI DKIRFFRVEQ SYAVKSGKWY FEFEAVTGGD MRVGWARPGC RPDIELGADD
QAFVFEGSKG QCWHQGSGFF GRSWQPGDVV GCMINLDDKS IIFTLNGELL ITSKGSELAF
ADFAIENGFV PICALGLSQI GRMNLGMDAS TFKYYTMCGL QEGFEPFAVN MNRDVAMWFS
NAYQHLSMCQ KTILTLRKHS QEIAPPSTTY FYSLRIFAGQ DPSSVWVGWV TPDYHFYSEN
FDLNKNCTVT VTLGDERGRV HESVKRSNCY MVWGGDVIAN SQRSGRSNVD IEIGCFVDLA
TGMVSFTANG RELGTCYQVE PNTKLFPATF LQPTSTNLIQ FELGKLKNTM PLSAAIFKSE
ERNPIPQCPP RLDVQTITPV LWSRMPNSFL RVETERVSER HGWVVQCLEP LQMMALHIPE
ENRCVDILEL CEQEDLMMFH YHTLKLYSSV SALGNTRVAY ALCSHVDVSQ LFFTIDNQYL
PGLLRSGFYD LLISIHLEHA KQAKLMMSNE FIIPVTDETR NIKLYPDETK KHGLPGVGLS
TCLKPGFNFS TPCFIATTED HQTSIPEIPL EILKSKAISM LTEAVQCSGS HIRDPVGGQV
AFQFVPVLKL IATLLIMGVF DDDDVKQVLL LIDPTVFGDH KEETEERTEK EEVTQVEEKA
VEAGEKAIKQ TKAPAKGLLQ TRLPESVKLQ MCHLLNYFCD CELQHRVEAI VSFADRYVSK
LQYNQKYRYN ELMQALNMSA ALTAKKTKEF RSPPQEQINM LLNFQLGEDC PCPEEIREEL
YEFHDDLLIH CGIPLEEEEE EEEDSSLTGK LRSLMYKIKG PPKAEKLEPK EEEEKAPTTL
KELISQTMVR WSQEDQIQDP ELVRIMYSLL RRQYDSIGEL LQALRKAYTI SAASVKDTIN
LLAALGQIRS LLSVRMGKEE ELLMINGLGD IMNNKVFYQH PNLMRVLGMH ETVMDVMVNV
LGGDKSQQIA FPKMVASCCR FLCYFCRISR QNQKAMFEHL SYLLENSSVG LAFPSMRGST
PLDVAAASVM DNNELALALE EPDLDKVVTY LAGCGLQSCP VLLAKGYPDI GWNPIEGERY
LSFLRFAVFA NSESVEENAS VVVKLLIRRP ECFGPDLRGE GGNGLLAAMQ EAIRISENPS
RDLPSQAYKR EGEEEEEEEE EETVHMGNAI MSFYSALIDL LGRCAPEMHL IQSGKGEAIR
IRSILRSLVP TEDLVGIISI PLKLSTVNKD GTVNEPDMSA SFCPDHKAPM VLFLDRVYGI
KDQSFLLHLL EVGFLPDLRA SASLDTLLTN HYEQCWKYYC LPSGMGSYGI AAEEELHLTE
KLFWGIFDSL SHKFLSLLQK YDPELFRMAL PCLSAIAGAL PPDYLDTRIM STLEKQTSVD
PEGNFDPKPV STSNLVLPEK LEYIVSKYAE HSHDKWAFEK TNSGWKYGVS LDENMKTHPL
IRPFKTLAEK EKEIYRWPAR ESLKTMLALG WSLERTKEGG EAIIHQRENE KLRSISQSSQ
GNGYSPTPLD LSNVALSREL QGMVEVMAEN YHNIWAKKKK MELESKGGGS HPLLVPYDTL
TAKEKSRDRE KAQELFKFLQ VNGIIISRGL NDMELDASSM EKRFAFKFLK KILKYVDSAQ
EFIAHLEAIV TSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHCLYFLSSP SKTLSSSGYA
SNKEKEMVAS LFCKLAALVR HRISLFGSDS ATMVNCLHIL AQSLDTRTVM KSGSELVKAG
LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT SIFEHISQYH
FGIDLLSSIR CPLGMSDDLV GFGINADDRG IRDTGVGDVQ VSCYRILCSL YSLGTGKNIY
VERQRPALGE CLASLAAAIP VAFLEPSLNH YNPLSVFNTK SARERAILGM PDTVEEMCPE
IPQLERLIKE INDLAESGAR YTEMPHVIEV ILPMLCNYLS YWWERGSESV PQSAGPCCTM
ITSEHLSIVL GNILKIINNN LGIDEASWMK RIAVYAQPII SKARPDLLRS HFIPTLDKLK
KKAMKIVMEE EQLKADSKND TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRANWLKK
PDADSDELFR MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDTKS KMSKRDTDEE
VKEHLRNNLH LQEKSDDPAV KWQLNLYKDI LKSDGPTDPE KNVERVQRIS AALYHLEQVE
QPLRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPRHRSI NLFLNGYQNF WIETEEYSFE
EKLVQDLATS PKKDEEEEEE TEKNHPDPLH QIILYFSRSA LTERSNLEHD PLYIAYSAMM
AKEKEMEKQR TLYQQARLHD RGAAEMVLQM ISASKGHTGP MVVETLKLGI AILNGGNTIV
QQKMLDYLKE KKDDGFFQSL SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GTREKVLQHD
EFTRDLFRFL QLLCEGHNND FQNYLRTQMG NTTTVNIIIS TVDYLLRLQE SISDFYWYYS
GKDVIDESGQ RNFSKALAVT KQIFNSLTEY IQDSAQIELL KELLDLLKDM VVMLLSLLEG
NVVNGTIGKQ MVDTLVESSS NVEMILKFFD MFLKLKDLTN SDAFKEYDPD GKGIISKKEF
QKSMEAQKQY IQSEIEFLLS CTEADENDMF NYVDFVERFH EPAKDIGFNV VVLLTNLSEH
MPNDPRLQSL LEPAESVLNY FEPYLGRIEI MGGAKKIERV YFEISESSRM QWEKPQVKES
KRQFIFDVVN EGGEQEKMEL FVNFCEDTIF EMQLASQISE TDSSERPDEE DEAESAYVMD
IGVDEEEEKS LEPASAFAVA CVAVKKNVAN FFKMVTVKNL RKQYRKVKKM TVKEMVKVFF
SFFWILFVGT FQMFFSIVWG IFQILWSTVF GGGLVEGAKN IKVTKILGDM PDPTQFGIHD
DVMEAEKAEV AEHGIRAELG EFVKSEKGET DIIADIFGIP TKKEGSKHGH DAGLGDIAEI
LGTEIQTPLE NTVHKKKRLQ ISEIAKEAGT QRKAEAEKAD MEDGEKQDKA KEVQSEQLEE
GKMKKKKRRH GQKIEKPEAV MANFFKALEI YQTKMLVTEE PLDEVEEDSN LWNSFAEEEE
EEGMVFFVLE EMVRTIMYYY SNNRRSFPNN YWDKFVKRKV INKYGDLYGA ERIAELLGLD
KSALDFSPVE ESKPEEASLV SWLSSIDTKY HIWKLGVVFT DNSFLYLAWY TTMSILGHYN
NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK
SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDPYEMYRIV FDITFFFFVI
VILLAIIQGL IIDAFGELRD QQEQVREDME TKCFICGIGN DYFDTTPHGF ETHTLQEHNL
ANYLFFLMYL INKDETEHTG QESFVWKMYQ ERCWDFFPAG DCFRKQYEDQ LG
//